Topics in Coagulation Donald M. Voltz, M.D. Assistant Professor of Anesthesiology Case Western Reserve University / University Hospitals of Cleveland.

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Presentation transcript:

Topics in Coagulation Donald M. Voltz, M.D. Assistant Professor of Anesthesiology Case Western Reserve University / University Hospitals of Cleveland

Pre-Operative Intra-Operative

Primary Hemostasis CoagulationFibrinolysis Components of Hemostasis Endothelial Cells

Primary Hemostasis Components of Hemostasis

Coagulation Components of Hemostasis

Coagulation Cascade

Coagulation Factors

Vitamin K

Fibrinolysis Components of Hemostasis

Fibrinolytic Agents

Anticoagulants

Coagulation Cascade

Components of Hemostasis Endothelial Cells

Endothelial Cell Adenosine Prostaglandins vWF Nitric Oxide t-PA Thrombomodulin Heparin Sulfate Tissue Factor Pathway Inhibitor

Disorders of Coagulation

Platelet Disorders

Hereditary Disorders Thrombocytopenia Dysfunction Platelet Disorders

Factor Disorders

Hereditary Deficiencies Acquired Deficiencies

Factor Inhibitors

Perioperative Anticoagulation

Heparin

Heparin Mechanism of Action

Coumadin

Vitamin K

Hirudin

Asprin

Plavix

Treatment of Coagulopathy

Liver Transplantation

Trauma and Massive Transfusions

Cardiac Bypass Coagulopathies

Antifibrinolytics

Disseminated Intravascular Coagulation

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