The organization of the nervous system. Structure of the human cerebral cortex.

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Presentation transcript:

The organization of the nervous system

Structure of the human cerebral cortex

Sensory map

Structure of the human cerebral cortex Motor map

Neuromuscular junction

How to manipulate it ? Curare ACh-ase inhibitors Myastenia gravis Botulinum toxin Pesticides

Parkinson’s disease Basal ganglia Parkinson’s disease Basal ganglia

Parkinson’s disease Most common symptoms Parkinson’s disease Most common symptoms Shaking (tremor) at Rest Stiffness (rigidity) Slow Movement (bradykinesia) Balance Problems (postural instability)

Multiple sclerosis Myelin

Multiple sclerosis Demyelination

Multiple sclerosis Progression Multiple sclerosis Progression

AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) Mutation or defect in neuronal SOD activity Excess oxidative stress to neuronal mitochondria Degeneration of motor neurons Paralysis – muscular atrophy Exacerbated by glutamate neurotransmitter activity