The organization of the nervous system
Structure of the human cerebral cortex
Sensory map
Structure of the human cerebral cortex Motor map
Neuromuscular junction
How to manipulate it ? Curare ACh-ase inhibitors Myastenia gravis Botulinum toxin Pesticides
Parkinson’s disease Basal ganglia Parkinson’s disease Basal ganglia
Parkinson’s disease Most common symptoms Parkinson’s disease Most common symptoms Shaking (tremor) at Rest Stiffness (rigidity) Slow Movement (bradykinesia) Balance Problems (postural instability)
Multiple sclerosis Myelin
Multiple sclerosis Demyelination
Multiple sclerosis Progression Multiple sclerosis Progression
AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) AML Amyotrophic Lateral Sclerosis (Lou Gherig disease”) Mutation or defect in neuronal SOD activity Excess oxidative stress to neuronal mitochondria Degeneration of motor neurons Paralysis – muscular atrophy Exacerbated by glutamate neurotransmitter activity