This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic.

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Osteoporosis in Individuals with Spinal Cord Injury

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This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis Jayanand Manjhi, PhD; Suneel Kumar, MSc; Jitendra Behari, PhD; Rashmi Mathur, PhD

This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Aim – Investigate effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. Relevance – SCI-induced osteoporosis is most rapid and severe form of osteoporosis. – Pulsed electromagnetic field therapy is reported to promote peripheral nerve regeneration, osteogenesis, and SCI recovery.

This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Method Adult Wistar rats were equally divided into 3 groups: – SCI and SCI+MF: complete spinal cord transection. – Sham: laminectomy only. 1 d post-SCI: exposed to ELF-MF or sham exposed. Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. All rats were sacrificed 8 wk post-SCI: – Tibias and femurs were isolated for bone mineral content (BMC), bone mineral density (BMD), and biochemical status analyses.

This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Results BBB score decreased post-SCI, which partially recovered after ELF-MF. SCI rats (vs sham): – Statistically significant decrease in BMC, calcium, phosphorus, carbon, BMD, and biochemical level, which attenuated in SCI+MF rats except carbon content. Electron microscopic study revealed enhanced microstructural composition and compactness in cortical and trabecular parts of treated bones.

This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Example of spinal cord 8 wk post-SCI in SCI and SCI+MF rats. Note areas of continuity in spinal cord and smaller cavities vis-à- vis degeneration of neurons (arrow mark) in SCI+MF vs SCI group.

This article and any supplementary material should be cited as follows: Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30. Slideshow Project DOI: /JRRD JSP Conclusion Results suggest that chronic ELF-MF exposure to SCI rats effectively attenuates SCI-induced osteoporosis.