RCGP England: ‘influenza and influenza-like illness’ <50 baseline Consultation rate.

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Presentation transcript:

RCGP England: ‘influenza and influenza-like illness’ <50 baseline Consultation rate

No of Deaths Consultation/100,000

RCGP/PHLS Samples & PCR +ve by Week of Sample Date (2000/2001) No of samples & isolates RCGP index per 100,000

RCGP Age Distribution of PCR % Positive, % PCR Positive

Community & Hospital Isolates, by Week of Sample Date No of isolates RCGP Index per 100,000

Influenza Types by Week of Sample Date, 2000/2001 No of isolates

Age Distribution of Isolates, 2000/2001 No. of flu isolates

REGIONAL DISTRIBUTION OF INFLUENZA ISOLATES, 2000/2001 Cumulative Total from Week 40/2000 (2nd October 2000) to Week 3/2001 (21st January 2001). A(H1N1)BTotal Positive NorthCentralSouthScotlandWales Community Samples Community Isolates % Positive6.8%5.8%7.1%01.9% Hospital Isolates All Isolates

CROSS REACTIVITY OF ENGLAND H1N1 STRAINS January 2001Haemagglutination Inhibition Post infection ferret sera < = <40 * vaccinated

PHYLOGENETIC TREE - INFLUENZA AH1N1 VIRUSES A/PERTH/15/95 A/ENG/37/96 A /BAYERN/7/95 A/ENG/135/00 A/ENG/704/97 A/ENG/575/98 A/ENG/192/00 A/ENG/266/95 A/TEXAS/36/91 A/NEWCALEDONIA/20/99 * A/ENG/190/00 A/HK/52/95 A/BEIJING/262/95 A/ENG/644/99 A/TW/1/86 (% distance between sequences * denotes current vaccine strain)

CROSS REACTIVITY OF ENGLAND B EPIDEMIC STRAINS January 2001Haemagglutination Inhibition 8AD virus <=<20 * vaccinated

PHYLOGENETIC TREE - INFLUENZA B VIRUSES B/ENG/224/00 B/SCOTLAND/24/99 B/ENG/197/00 B/ENG/671/98 B/ENG/889/99 B/ENG/615/98 B/SICHUAN/379/99 B/SCOTLAND/18/97 B/YAMANASHI/166/98 * B/ENG/239/97 B/ENG/362/96 B/ENG/296/96 B/BEIJING/184/93 B/QIN/102/91 B/PANAMA/45/90 B/HARBIN/7/94 B/ENG/115/95 B/HK/46/94 B/VIC/2/87 (% distance between sequences * denotes current vaccine strain)

CONCLUSIONS Low level of influenza activity 2000/2001 Predominantly AH1N1 strains circulating Majority of strains are A/NewCaledonia/20/99-like Small number are A/Bayern/7/95-like Onset of influenza B circulation Influenza B strains are B/Yamanashi/166/98-like Closely-related antigenically and genetically to B/Sichuan/379/99