ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Scott C. Denne, MD Associate Director, Indiana CTSI April 25, 2011 Plenary Session.

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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH Scott C. Denne, MD Associate Director, Indiana CTSI April 25, 2011 Plenary Session II: “Research Highlights of the Year”

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH Research Inventions and Scientific Innovation (RISC) Grants Pilot program supports research that leads to IP generation K Basic Science Scholar Awards Career development supports PhD basic scientists doing translational research Project Development Team Pilot Funding Multidisciplinary team supports development of preliminary data for external grant submissions Unique Pilot Funding Programs of the Indiana CTSI

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH Project Development Teams (PDTs) Multidisciplinary teams serve as “one stop shops” by providing investigators access to protocol/project development; pilot funding; biostatistics; IRB/regulatory and nursing support Helps investigators develop ideas/hypotheses into well-designed translational projects Facilitates collaboration with other investigators Provides access to other CTSI resources

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH PDT projects - portfolio by stage Preclinical Sciences Pediatric Sciences BP Sciences Purdue Imaging BENC H Basic Science Research Preclinical Studies Animal Research Clinical Sciences Notre Dame BEDSIDE Human Clinical Research Controlled Observational Studies Phase 3 Clinical Trials PRACTICE Clinical Practice Delivery of Care Identification of New Clinical Questions and Gaps in Care T1 Case Series Phase 1 and 2 Clinical Trials T2 Guideline Development Meta-analyses Systematic Reviews T3 Dissemination & Implementation Research Health Systems Redesign Applied Health IT Proof of Model Drug Concept Dev Dev TRIP