Vancomycin-Modified Implant Surface Inhibits Biofilm Formation and Supports Bone-Healing in an Infected Osteotomy Model in Sheep by Suzanne Stewart, Stephanie.

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Presentation transcript:

Vancomycin-Modified Implant Surface Inhibits Biofilm Formation and Supports Bone-Healing in an Infected Osteotomy Model in Sheep by Suzanne Stewart, Stephanie Barr, Julie Engiles, Noreen J. Hickok, Irving M. Shapiro, Dean W. Richardson, Javad Parvizi, and Thomas P. Schaer J Bone Joint Surg Am Volume 94(15): August 1, 2012 ©2012 by The Journal of Bone and Joint Surgery, Inc.

The top row shows immunofluorescent staining and confocal laser imaging of four different surface modifications of titanium slugs, confirming vancomycin tethering (Invitrogen anti- vancomycin Alexa Fluor 488, ×10). Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Immunofluorescent staining and confocal laser imaging confirming vancomycin tethering on two regions of the plate (anti-vancomycin Alexa Fluor 488, ×10). Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Osteotomies repaired with vancomycin-treated (Figs. 3-A and 3-B) and untreated, control plates (Figs. 3-C and 3-D). Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Representative gross pathologic photograph of the surgical site in an animal in the vancomycin- treated cohort at ninety days postoperatively, during explantation and tissue harvesting (Fig. 4- A), demonstrates a normal soft-tissue envelope with little to no... Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Representative photomicrographs of calcified histologic sections, comparing fracture-healing at three months after osteotomy in the control and vancomycin cohorts at ×2 (Figs. 5-A and 5-E), ×10 (Figs. 5-B and 5-F), ×20 (Figs. 5-C and 5-G), and ×40 (Fig. 5-D... Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.

Immunofluorescent staining and confocal laser imaging of explanted plates to assess vancomycin stability and biofilm formation (anti-vancomycin Alexa Fluor 488, ×10). Suzanne Stewart et al. J Bone Joint Surg Am 2012;94: ©2012 by The Journal of Bone and Joint Surgery, Inc.