Appendix 1 Jeong et al. A. mPPAR  0 6 12 18 (-)WYRosiGW CG269 1  M 1  M 1  M Relative reporter activity * ** B. hPPAR  0 5 10 15 20 (-)WYRosiGW CG269.

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Appendix 1 Jeong et al. A. mPPAR  (-)WYRosiGW CG269 1  M 1  M 1  M Relative reporter activity * ** B. hPPAR  (-)WYRosiGW CG269 1  M 1  M 1  M Relative reporter activity ** * * (-)WYRosiGWCG269 Relative reporter activity PPAR  C. # D. LXR Relative reporter activity (-)T1317WYRosiGWCG269 # E. Relative reporter activity EC 50 = 39 nM PPAR  (  M) // F. PPAR  EC 50 =2.69  M Relative reporter activity (  M) //

Appendix 2 Jeong et al. A. B.

Jeong et al. Appendix 3 * * * * B. PPAR  WY GW Rosi Trypsin CG * * A. * * Trypsin PPAR  WY GW Rosi CG

Jeong et al. Appendix 4 Fold of  -oxidation (-)WYRosiCG269 * * ACOCPT1 Relative gene expression # * # * * * * * * A. B.

Jeong et al. Appdneix 5 A aP2Acrp30LPLCD36 Relative gene expression 3T3-L1 # * * * * * * * * # # # # * * B aP2Acrp30LPLCD36 3T3-F442A Relative gene expression # # * * # # * * * * # # # * * Relative mRNA PPAR  (-)Rosi CG269 (-)Rosi CG269 (-)Rosi CG * * # * * * * * * *# * # * * ¶ ¶ ¶ ¶ ¶ ¶ aP2CD36 Acrp30 D. C.C aP2Acrp30LPL Relative gene expression WAT # * # # # * Veh WY Rosi CG269

Jeong et al. Appendix 6 A. B Total 246 Rosi 218 CG Upregulation Downregulation C. CxCl12 Retn PmvK Mthfd1l Iars Agpat3 Cfd Hadhb Ifi30 Veh CG269 CG269 Rosi 0.5  M 5  M 1  M

TNF  IL-1  IL-6iNOSMCP1COX2MMP9 Relative gene expression 3T3-F442A * * * * * ** * # # # # # ¶ ¶ ¶ ¶ ¶ # ¶ ¶ ¶ ¶ ¶ ¶ ¶ # ¶ ¶ ¶ ¶¶ ¶ ¶ Jeong et al. Appendix 7

Jeong et al. Average daily food intake (g) VehWYRosiCG269 Appendix 8

Jeong et al. Appendix 9 Relative gene expression * * * # * * *

Jeong et al. Appendix 10 VehWYRosiCG269