Herpes Virus.

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Presentation transcript:

Herpes Virus

Herpes Virus herpesviridae 8 types

Human herpes type Name 1 Herpes simplex-1 (HSV-1) 2 Herpes simplex-2 (HSV-2) 3 Varicella Zoster virus (VZV) 4 Epstein-Barr Virus (EBV) 5 Cytomegalovirus (CMV) 6 Human herpes virus-6 (HHV-6) 7 Human herpes virus-7 (HHV-7) 8 Human herpes virus-8 (HHV-8)

common properties shape and structure spherical, 120-200nm core capsid tegument envelope

common properties replication immediate-early proteins early proteins late proteins

common properties types of infection apparent infection latent infection integration infection congenital infection

Herpes simplex virus

Biological Propeties shape and structure

Biological Propeties Typing HSV-1 HSV-2

Biological Propeties Cultivation

Pathogenesis Source: human transmission HSV-1: contact HSV-2: sex contact; vertical transmission

Pathogenesis types of infection Primary infection Latent infection and reactivation

Primary infection HSV-1 HSV-2 6m-2y herpes gingivostomatitis Herpes keratitis Eczema herpeticum HSV Encephalitis HSV-2 Adults: Genital herpes Neonates: HSV infection of neonates

Latent infection and reactivation HSV → primary infection → a little amount of virus remained → HSV-1: 三叉神经节, 颈上神经节 HSV-2:骶神经节 → latent infection → reactivated by several stimulators → arrive at the mucosa that was initially infected

Varicella-Zoster Virus

Varicella-Zoster Virus source: human Transmission respiratory aerosols direct contact with skin lesions

Disease VZV → viremia → chicken pox → 脊髓后根神经节; 脑神经的感觉神经节 → reactivation → shingles

Epstein-Barr Virus

Epstein-Barr Virus Burkitt‘s lymphoma nasal pharyngeal carcinoma infectious mononucleosis

Epstein-Barr Virus source: human transmission saliva sex contact

Epstein-Barr Virus types of infection multiplication infection: epithelial cells latent infection: B lymphocytes transformation

Epstein-Barr Virus Diseases Infectious mononucleosis Burkitt's lymphoma Nasopharyngeal cancer

Human Cytomegalovirus (HCMV)

HCMV source: human Transmission maternal-infant transmission close contact sexually transmitted blood transfusions and transplants

Disease Congenital infection Perinatal infection placenta Cytomegalic inclusion disease Perinatal infection adolescent and adult infection Granular fever Disease in immunosuppressed patients transformation and carcinogenesis

Human herpes virus 6

Human herpes virus 6 latent infection in T cells Children: exanthem subitum Adults: mononucleosis

Virus Treatment Vaccination HSV ACV (acyclovir) No VZV ACV Live attenuated vaccine virus EBV being developed HCMV GCV (Ganciclovir