Alzheimer's disease M O Jamali, H Saeed & T Mathew

 Alzheimer’s is the most common form of dementia within the populace today. It is an incurable degenerative disorder which is terminal.  The disease was first discovered by the German scientist Alois Alzheimer in 1906  Alzheimer's disease (AD)—also called Alzheimer disease, senile dementia of the Alzheimer type (SDAT), primary degenerative dementia of the Alzheimer's type (PDDAT)

 The exact cause of Alzheimer's disease isn't known, although some risk factors are known. The risk of developing the disease increases with age, for example.  There's a higher risk of Alzheimer's if a family member has the disease. However, inherited genetic factors are responsible in only a small number of families.  When the disease is inherited, it tends to lead to early onset of Alzheimer's, usually between the ages of 35 and 60. One of several different genes may be at fault, such as the presenilin-1 gene on chromosome 14 or the amyloid precursor protein gene on chromosome 21.  Most cases of Alzheimer's develop later in life and the genetic link is weaker. The genes at fault here are those for apolipoprotein E. Problems with these genes increase the risk of disease but don't make it certain.

 Memory and the ability to think clearly are gradually lost over time. There may also be a change in personality. Someone who used to be a calm person may become agitated or upset more easily, for example. Behaviour problems and communication difficulties may also occur.  People with severe Alzheimer's may find it difficult to perform everyday tasks, such as dressing, washing and eating. As time passes they may not recognise people or their surroundings, so it's common for them to go for a walk and get lost.  Other problems, such as depression, may also develop.  A ten point list can be found at: alzheimers.asp alzheimers.asp

 There's no cure for Alzheimer's disease, but drugs are available that may specifically slow the loss of mental function in mild to moderate cases. These include the acetylcholinesterase inhibitors such as donepezil, rivastigmine and galantamine, which improve brain cell communication, and memantine, a glutamate blocker which protects brain cells against damage.  Other drugs such as aspirin and the cholesterol lowering treatments such as statins may be of use in slowing the vascular damage that may also play a role in many types of dementia including Alzheimers.

 There's some evidence the herb ginkgo biloba and possibly also vitamin E may help delay progression of the disease  Support and help can be provided by social services for those with Alzheimer's disease and their carers, but full-time residential care may be necessary in the later stages of the disease.  Tests to identify those in the early stages of Alzheimer's disease are in development.

 There are currently 750,000 people with dementia in the UK.  There are over 16,000 younger people with dementia in the UK.  There will be over a million people with dementia by  Two thirds of people with dementia are women.  One third of people over 95 have dementia.  60,000 deaths a year are directly attributable to dementia.  The financial cost of dementia to the UK is over £20 billion a year.  64% of people living in care homes have a form of dementia.  Two thirds of people with dementia live in the community while one third live in a care home.

 The same risk factors for heart disease are believed to increase the risk of Alzheimer's. So although there's no definitive way to prevent the disease, not smoking, keeping blood pressure and cholesterol at healthy levels, taking regular exercise, maintaining a healthy weight and eating a healthy diet rich in the antioxidant vitamins C and E and oily fish are all sensible.  Some research has suggested that taking non- steroidal anti-inflammatory drugs (NSAIDs) or cholesterol-lowering statin drugs may lessen the risk of Alzheimer's disease  Other research into brain stem cell therapy, antioxidant therapy and a vaccination to prevent build up of plaques on the brain is also ongoing

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