Figure 1 A B * C 100 x 200 x 400 x D GSEControl

Mafbx β-tubulin Control GSE * Figure 2

Figure 3 Control GSE * Cleaved-caspase-3 Pro-caspase-3 β-tubulin Control GSE * * A B C 200 μm

Total-Akt p-Akt β-Tubulin Control GSE * * Figure 4

* * p-p65 β-Tubulin Control GSE p65 * * A B Figure 5

Figure 6 Control GSE Pro-capase1 Cleaved capase1(p20) NLRP3 β-tubulin * P=0.07 A B C *

Figure 7 Protein kinase B Inflammasome Muscle atrophy GSE Protein degradation Apoptosis pro-IL-1β p65 p50 NLRP3 ASC Pro-caspase-1 inflammation pro-IL-18 TNF  mature IL-1β mature IL-18 P P