A Draft Sequence of the Neandertal Genome by Richard E. Green, Johannes Krause, Adrian W. Briggs, Tomislav Maricic, Udo Stenzel, Martin Kircher, Nick Patterson,

Slides:



Advertisements
Similar presentations
From Africa to Aotearoa The story of human migrations.
Advertisements

By Peter Malinski. Mammoths are an extinct species that lived during the Pleistocene as recently as 10,000 years ago. Some mammoths have been recovered.
Patterns of population structure and admixture among human populations Katarzyna Bryc OEB 275br February 19, 2013.
T 5/5 exam #3 (bring cheat sheet) Sat. 5/9 optional final exam, 9am-noon.
1 Genome sizes (sample). 2 Some genomics history 1995: first bacterial genome, Haemophilus influenza, 1.8 Mbp, sequenced at TIGR first use of whole-genome.
Neandertal mtDNA evidence: reported 1997 Dr. Svante Pääbo (Max Planck Institute for Evolutionary Anthropology). mtDNA sequence from type specimen of “neanderthalensis”
New polymerases for old DNA: molecular breeding of polymerases for damage bypass and ancient DNA amplification Philipp Holliger MRC Laboratory of Molecular.
A high-resolution map of human
Haplotype Blocks An Overview A. Polanski Department of Statistics Rice University.
APPLICATIONS OF MOLECULAR PHYLOGENETICS
Finding Cancer Genes.
16. Molecular Phylogenetics
The 5300-year-old Helicobacter pylori genome of the Iceman by Frank Maixner, Ben Krause-Kyora, Dmitrij Turaev, Alexander Herbig, Michael R. Hoopmann, Janice.
Cancer Genome Landscapes
Food Security: The Challenge of Feeding 9 Billion People by H. Charles J. Godfray, John R. Beddington, Ian R. Crute, Lawrence Haddad, David Lawrence, James.
Scattering and Interference in Epitaxial Graphene by G. M. Rutter, J. N. Crain, N. P. Guisinger, T. Li, P. N. First, and J. A. Stroscio Science Volume.
Comment on “Chromosomal Instability and Tumors Promoted by DNA Hypomethylation” and “Induction of Tumors in Mice by Genomic Hypomethylation” by Allen S.
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution by Jeff Vierstra, Eric Rynes, Richard Sandstrom, Miaohua Zhang, Theresa.
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.
Response to Comment on “Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI” by Michael J. Minzenberg, Andrew.
The genetic prehistory of the New World Arctic by Maanasa Raghavan, Michael DeGiorgio, Anders Albrechtsen, Ida Moltke, Pontus Skoglund, Thorfinn S. Korneliussen,
1 Chromosome Evidence for Ancestry © 2008 Regents of the University of California. All rights reserved. Use for SGI Field Test only.
Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection by Kartik Chandran, Nancy J. Sullivan, Ute Felbor, Sean P. Whelan, and.
Comment on “A Complete Skull from Dmanisi, Georgia, and the Evolutionary Biology of Early Homo” by Jeffrey H. Schwartz, Ian Tattersall, and Zhang Chi Science.
W 7/30 exam #3 (bring cheat sheet) bonus #2 due W 8/6 optional final exam, during class time.
Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection by Thor A. Wagner, Sherry McLaughlin, Kavita Garg, Charles.
Current Problems in the Management of Marine Fisheries by J. R. Beddington, D. J. Agnew, and C. W. Clark Science Volume 316(5832): June 22, 2007.
Lecture 24: Human Origins and Signatures of Selection April 11, 2014.
Extract DNA and RNA from the same E. coli culture
by Miguel Carneiro, Carl-Johan Rubin, Federica Di Palma, Frank W
by Leighton J. Core, Joshua J. Waterfall, and John T. Lis
Human Evolution: Turning Back the Clock
by Stephen K. Gire, Augustine Goba, Kristian G. Andersen, Rachel S. G
A. Verzeletti, V. Cortellini, S. Cisana, S. Pretto, N. Cerri, F
Michael W. Smith, Nick Patterson, James A. Lautenberger, Ann L
Long-read sequence assembly of the gorilla genome
by Manuel A. Rivas, Matti Pirinen, Donald F
by Richard E. Green, Edward L
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors  Michael Dannemann, Aida M.
Long-Range LD Can Confound Genome Scans in Admixed Populations
Fig. 4. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive and HBeAg-negative chimpanzees. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive.
Neandertal DNA Sequences and the Origin of Modern Humans
Variant arose about years ago
Fig. 2. Response to repeat dosing of chimpanzees with ARC-520.
Ancient DNA: Would the Real Neandertal Please Stand up?
DNA transfer by different parts of a hand
Student-Directed Discovery of the Plant Microbiome and Its Products
The Antisense Transcriptomes of Human Cells
A Complete mtDNA Genome of an Early Modern Human from Kostenki, Russia
STAT Genes Found in C. elegans
The Human Condition—A Molecular Approach
The Predecessors Within
Volume 134, Issue 3, Pages (August 2008)
Positive selection on gene expression in the human brain
A. Verzeletti, V. Cortellini, S. Cisana, S. Pretto, N. Cerri, F
The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals
by Yali Xue, Javier Prado-Martinez, Peter H
by Benjamin Vernot, Serena Tucci, Janet Kelso, Joshua G
Congratulations! Now Get to Work
by Jacob O. Brunkard, Anne M. Runkel, and Patricia C. Zambryski
Fig. 5. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative chimpanzees. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative.
Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China by Y. Guan, B. J. Zheng, Y. Q. He, X. L. Liu,
A method to identify a large number of mammalian species in the UK from trace samples and mixtures without the use of sequencing  Shanan S. Tobe, Adrian.
Volume 23, Issue 7, Pages (April 2013)
Suboptimization of developmental enhancers
Schematic representation of the SyngenicDNA approach.
Comparison of the frequency of nucleotide variation in the mtDNA D-loop region between stomach and other tumor cell lines. Comparison of the frequency.
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors  Michael Dannemann, Aida M.
by Manuel A. Rivas, Matti Pirinen, Donald F
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees
Presentation transcript:

A Draft Sequence of the Neandertal Genome by Richard E. Green, Johannes Krause, Adrian W. Briggs, Tomislav Maricic, Udo Stenzel, Martin Kircher, Nick Patterson, Heng Li, Weiwei Zhai, Markus Hsi-Yang Fritz, Nancy F. Hansen, Eric Y. Durand, Anna-Sapfo Malaspinas, Jeffrey D. Jensen, Tomas Marques-Bonet, Can Alkan, Kay Prüfer, Matthias Meyer, Hernán A. Burbano, Jeffrey M. Good, Rigo Schultz, Ayinuer Aximu-Petri, Anne Butthof, Barbara Höber, Barbara Höffner, Madlen Siegemund, Antje Weihmann, Chad Nusbaum, Eric S. Lander, Carsten Russ, Nathaniel Novod, Jason Affourtit, Michael Egholm, Christine Verna, Pavao Rudan, Dejana Brajkovic, Željko Kucan, Ivan Gušic, Vladimir B. Doronichev, Liubov V. Golovanova, Carles Lalueza-Fox, Marco de la Rasilla, Javier Fortea, Antonio Rosas, Ralf W. Schmitz, Philip L. F. Johnson, Evan E. Eichler, Daniel Falush, Ewan Birney, James C. Mullikin, Montgomery Slatkin, Rasmus Nielsen, Janet Kelso, Michael Lachmann, David Reich, and Svante Pääbo Science Volume 328(5979): May 7, 2010 Published by AAAS

Fig. 1 Samples and sites from which DNA was retrieved. Richard E. Green et al. Science 2010;328: Published by AAAS

Fig. 2 Nucleotide substitutions inferred to have occurred on the evolutionary lineages leading to the Neandertals, the human, and the chimpanzee genomes. Richard E. Green et al. Science 2010;328: Published by AAAS

Fig. 3 Divergence of Neandertal and human genomes. Richard E. Green et al. Science 2010;328: Published by AAAS

Fig. 4 Selective sweep screen. Richard E. Green et al. Science 2010;328: Published by AAAS

Fig. 5 Segments of Neandertal ancestry in the human reference genome. Richard E. Green et al. Science 2010;328: Published by AAAS

Fig. 6 Four possible scenarios of genetic mixture involving Neandertals. Richard E. Green et al. Science 2010;328: Published by AAAS