Patient IDSexAge Pathology Nephrectomy MSKCC classification NCCN classification Prior therapy SUVmaxSUVmax site typegrading 1M58unknown NoPoor non13.3lung 2M63sarc / clear3YesPoor IFN15.2local recurrence 3M73clear2YesFavorableNot PoorIFN IL8.2lung 4M61papillary3NoIntermediate Poornon8.8primary 5F72clear1NoIntermediateNot Poornon5.2primary 6F55clear2NoIntermediateNot PoorIFN IL6.8primary 7M57papillary2YesIntermediate PoorN4.0bone 8M59clear2YesIntermediate Poornon7.4bone 9M68clear3YesIntermediateNot PoorIFN5.7bone 10F57clear2YesPoor IFN N9.1lymph node 11M75clear2YesIntermediateNot PoorIFN5.3muscle 12M58clear3YesFavorableNot PoorIFN8.5local recurrence 13F61clear2YesIntermediate PoorIFN C4.3pancreas 14M59clear2YesIntermediateNot Poornon1.4lung 15M61clear2YesIntermediatePoorIFN7.7lymph node 16M73clear2NoPoor non16.6primary 17F32papillary3YesFavorableNot Poornon16.1uterus 18M56papillary2YesIntermediateNot PoorC7.0lung 19M68clear2YesIntermediatePoornon9.0bone 20M61clear2YesIntermediateNot Poornon5.6IVC thrombus 21F56sarc /clear3YesIntermediate PoorIFN10.0 contralateral kidney 22M62clear3NoPoor non12.0primary 23M61clear3NoPoor non14.3primary 24M82clear1YesIntermediate Poornon5.1bone 25M69papillary3YesFavorableNot Poornon13.4lymph node 26M66clear1YesIntermediateNot PoorIFN8.2lung Table 1. Characteristics of the 26 patients

Table 2. Univariate and multivariate Cox survival analyses of SUVmax and various clinical parameters 95% CIs P value Risk Factors SUVmax (continuous variable) PS (<80%) LDH(>1.5x upper limit of normal) Ca (>10mg/dl) Nephrectomy (no) Hb (<lower limit of normal) Interval (<1 year) Metastatic site (>2) HR P value X HR %CIs Univariate analysis Multivariate analysis* *Cox multivariate model with backward elimination procedures was applied for SUVmax, PS, LDH, Ca and Nephrectomy. The p-value of variables not statistically significantly associated with survival in the best Cox model are indicated by an X.

Table 3. Univariate and Multivariate Cox Analyses of SUVmax versus Standard Prognostic Classification for Advanced RCC Risk factors SUVmax (continuous variable) MSKCC classification* NCCN classification** *Poor risk vs Favorable risk/Intermediate risk **Poor risk vs not poor risk ***multivariate analysis was performed using SUVmax and MSKCC classification HR P-value %CIs HR P-value %CIs Univariate analysis Multivariate analysis ***