Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models JY Zhang, V Taranenko, D Zhang, X. George Xu, Rensselaer Polytechnic.

Slides:



Advertisements
Similar presentations
CT Organ Dose - Part 1 Estimating organ dose for patients Michael F. McNitt-Gray, Ph.D., DABR David Geffen School of Medicine at UCLA.
Advertisements

Energy deposition and neutron background studies for a low energy proton therapy facility Roxana Rata*, Roger Barlow* * International Institute for Accelerator.
Consent for Research Study A study for patients newly diagnosed with advanced glioblastoma (brain cancer): Learning whether a PET scan with F-fluoromisonidazole.
MOHAMMAD HUSSIEN, NICHOLAS SPYROU & ANDY MA ANTHROPOMORPHIC VOXEL PHANTOM EFFECTIVE NEUTRON DOSES OUTSIDE A LINAC ROOM Department of Physics, University.
Radiation Exposure, Dose and Relative Biological Effectiveness in Medicine Background Image:
Radiation Therapy (RT). What is cancer? Failure of the mechanisms that control growth and proliferation of the cells Uncontrolled (often rapid) growth.
Reduced Dose of Proton CT Compared to X-Ray CT in Tissue-Density Variation Sensitivity T. Satogata, T. Bacarian, S. Peggs, A.G. Ruggiero, and F.A. Dilmanian.
MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry—Standardization of Nomenclature 5/15/2009.
Chapter 4 Radioactivity and Medicine A CT scan (computed tomography) of the brain using X-ray beams.
Kirov A S, MSKCC Overview of Geant4 Use and Issues in Imaging: Emission Tomography (PET and SPECT) Assen S. Kirov Department of Medical Physics Memorial.
Radioactive Drug Research Committee
G4NAMU GEANT4 North America Medical Users Organization (G4NAMU) GEANT4 in external beam therapy Harald Paganetti.
Tissue inhomogeneities in Monte Carlo treatment planning for proton therapy L. Beaulieu 1, M. Bazalova 2,3, C. Furstoss 4, F. Verhaegen 2,5 (1) Centre.
PHYSICS IN NUCLEAR MEDICINE: QUANTITAITVE SPECT AND CLINICAL APPLICATIONS Kathy Willowson Department of Nuclear Medicine, Royal North Shore Hospital University.
At the position d max of maximum energy loss of radiation, the number of secondary ionizations products peaks which in turn maximizes the dose at that.
Patient Dosimetry in Radiology, Management Center Europe, June
Design and Scheduling of Proton Therapy Treatment Centers Stuart Price, University of Maryland Bruce Golden, University of Maryland Edward Wasil, American.
Department of Radiation Oncology and BIO-X, School of Medicine Stanford University Molecular Imaging Program at Stanford MIPS Monte Carlo treatment planning.
COMPUTERS AND RADIATION THERAPY/ONCOLOGY Lydia Eichler CIS 109.
Percutaneous CT-Guided Cryotherapy of Renal Masses: Long-term Follow-up and Morbidity. Hussein D. Aoun, M.D Wayne State University / Detroit Medical Center.
TWO FIELD BREAST PLAN VS. OPTIMIZED CONFORMAL BREAST PLAN: COMPARISON OF PLAN PARAMETERS Authors: Borko Basarić, Ozren Čudić, Milan Teodorović, Borislava.
Shannon M MacDonald 1, Salahuddin Ahmad 2, Stefanos Kachris 3, Betty J Vogds 2, Melissa DeRouen 3, Alicia E Gitttleman 3, Keith DeWyngaert 3, Maria T Vlachaki.
ALARA Planning and Teaching Tool Based on Virtual-Reality Technologies Di Zhang 1, X. George Xu 1, D. Hussey 2, S.Bushart 2 1 Nuclear Engineering and Engineering.
Proton Therapy for Chondrosarcomas of the Skull Base and Cervical Spine: Long-term Experience at Loma Linda University Medical Center D. Y. Kim 2, R. W.
Applications of Geant4 in Proton Radiotherapy at the University of Texas M.D. Anderson Cancer Center Jerimy C. Polf Assistant Professor Department of Radiation.
Milestones M5 and M6 Mid-Term Review, October 2013M. Silari – ARDENT overview1 M5: comparison of detector technologies (WP1) M6: choice of detector technology.
Joseph Perl SLAC National Accelerator Laboratory Scientific Computing Workshop 20 June 2011 Work supported in part by the U.S. Department of Energy under.
Ian C. Smith 1 A portal-based system for quality assurance of radiotherapy treatment plans using Grid-enabled High Performance Computing clusters CR Baker.
CT physics and instrumentation
Internal Radiation Dosimetry Lab 9. Radiation Measurement We use different terms depending on whether: 1.The radiation is coming from a radioactive source.
NUCLEAR VS. CHEMICAL CHEMICAL reactions involve rearranging of atoms: e.g., H 2 +O 2  H 2 O No new atoms are created. Chemistry involves electrons only.
Ye, Sung-Joon, Ph.D. Ove, Roger, M.D., Ph.D.; Shen, Sui, Ph.D.
Monte carlo radiation transport simulation in dosimetry from environmental modeling to multimillion voxel human phantom Valery Taranenko Institute of Radiation.
Neutron Dose Per Fluence and Weighting Factors for Use at High Energy Accelerators (Submitted to Health Physics) J. Donald Cossairt, Ph.D., C.H.P. Kamran.
Consent for Research Study A study for patients newly diagnosed with advanced glioblastoma (brain cancer): Learning whether a PET scan with F-fluoromisonidazole.
Evaluation of absorbed fractions for beta- gamma radionuclides in ellipsoidal volumes of soft tissue through Geant4 Ernesto Amato 1, Domenico Lizio 2 and.
Outline Intro: voxel phantom + MCNPX Building geometry
Comparison of MC and TP Dosimetry Simulations for Cancer Treatment Raymond Mumme May 12, 2014 Supervisor: Thiago Lima (PhD student) Head Supervisor: Dr.
ESTRO, Geneva 2003 The importance of nuclear interactions for dose calculations in proton therapy M.Soukup 1, M.Fippel 2, F. Nuesslin 2 1 Department of.
TLD POSTAL DOSE QUALITY AUDIT FOR 6MV AND 15MV PHOTON BEAMS IN RADIOTHERAPY CLINICAL PRACTICE Sonja Petkovska 1, Margarita Ginovska 2, Hristina Spasevska.
Photoneutron Distributions around 18 MV X-ray Radiotherapy Accelerators using Nuclear Track Detectors Fazal-ur-Rehman, H. Al-Ghamdi, M. I. Al-Jarallah.
Radiation Therapy Trials - Quality Assurance:  patient safety  adherence to protocol constraints  uniformity of patient treatments  efficient review.
Flair development for the MC TPS Wioletta Kozłowska CERN / Medical University of Vienna.
Dae-Hyun Kim Dept. of Biomedical Engineering The Catholic University of Korea Department of Biomedical Engineering Research Institute.
Se Byeong Lee, Ph.D Chief Medical Physicist Proton Therapy Center in NCC, Korea.
MCS overview in radiation therapy
W. Udo Schröder, 2007 Applications Applications of Nuclear Instruments and Methods 1.
People with chronic pain are often prescribed methadone, a type of analgesic medicine to reduce pain. This medicine is also given.
Methods & Materials (continued)
J Cho, G Ibbott, M Gillin, C Gonzalez-Lepera, U Titt and O Mawlawi
Medical physics AMMAR ALHASAN University of Central Florida
Radiation related Procedures and in-Utero Effects
EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy
Quantitative Nuclear Medicine Imaging
Proton range verification with PET: 68Zn, Cu and polycarbonate activation SNMMI Young Investigator Symposium, Vancouver, June 9, 2013 Cho J1, Ibbott.
Very High Energy Electron for Radiotherapy Studies
A Brachytherapy Treatment Planning Software Based on Monte Carlo Simulations and Artificial Neural Network Algorithm Amir Moghadam.
Update on New Federal Guidance for Dose and Risk Assessment
Witold Matysiak (University of Florida Proton Therapy Institute)
Feasibility of using O-18 for PET proton range verification
Task Group 158 Measurement and Calculation of Doses Outside the Treatment Volume from External-beam Radiation Therapy Treatment Eric E Klein, Ph.D.
Yothin Rakvongthai, Georges El Fakhri, Ruth Lim, Ali A
Isotopes Objectives: 5.2 To identify the advantages & disadvantages of using isotopes in industry, medical science, basic research & in the environment.
Geant4 at IST Applications in Brachytherapy
Anthropomorphic Phantoms
Isotopes Objectives: 5.2 To identify the advantages & disadvantages of using isotopes in industry, medical science, basic research & in the environment.
Picture 1 10 protons 10 neutrons = an electron.
CHAPTER 22 Nuclear Chemistry
SBRT trial QA IROC GHG meeting at ESTRO May, 2017
Presentation transcript:

Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models JY Zhang, V Taranenko, D Zhang, X. George Xu, Rensselaer Polytechnic Institute, Troy, NY CY Shi Cancer Therapy and Research Center, San Antonio, TX

Project Motivation (Pregnant Female Models) High radio-sensitivity for the fetus Needs for accurate dosimetry –Occupational (if the pregnancy is declared) –Nuclear medicine –Radiation treatment of pregnant patients (increasing!) –Air traveling –non-ionizing radiation (RF etc) Models difficult to develop –Twice as many tissues and organs –3-month, 6-month and 9-month gestational periods –Medical images are rare

Project Goals 1) Development a new set of models of pregnant mother and fetus at the end of 3-, 6- and 9-month gestational periods 2) Compile organ dose parameters for external and internal irradiations

Existing Pregnant Female Models Stylized models - Stabin Chen 2004 From partial-body CT image set - Shi and Xu (2004) They are un-realistic and in-complete

Method: Flow Chart of Pregnant Female Model Development Model Extraction of 3D representation from CT Images (external uterine wall). This is a new approach!

Organ Masses Adjusted to ICRP References

From Surfaces to Voxels Surface Model Adjusted to ICRP reference values Voxel Model Geometry in MCNPX code Re-voxelize at any size (1mm shown here) Put into MC codes - MCNPX - EGSnrc

RPI-P3, RPI-P6, and RPI-P9 Models 9-month 6-month3-month

Results - Internal photon Specific Absorbed Fractions (RPI-P9 phantom)

Results - External photons RPI-P9 phantom; total fetal dose

Conclusion A series of pregnant female and fetus phantoms have been developed Organ masses are adjusted according to ICRP reference values External photon, electron, neutron and proton sources have been studied Internal photon and electron sources have been studied ICRP is hoped to adopt the RPI-P series as standard pregnant-female models

Visualization for RPI-P9 Pregnant Female Model (available at RRMDG.rpi.edu) Acknowledgements This work is supported by grants 1R42CA and 5R01CA from the National Institutes of Health Drs Mike Stabin and Keith Eckerman provided valuable help on ICRP data analysis