Outcome of 129 children after antenatal exposure to cancer treatment: Results of a case-control study from the International Network on Cancer, Infertility.

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Presentation transcript:

Outcome of 129 children after antenatal exposure to cancer treatment: Results of a case-control study from the International Network on Cancer, Infertility and Pregnancy registry Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands

129 study children born to mothers with cancer during pregnancy 129 control children born after an uncomplicated pregnancy and delivery 89 chemotherapy (+ surgery) 4 radiotherapy (+ surgery) 7 chemotherapy + radiotherapy (+ surgery) 1 trastuzumab 1 interferon-β 13 surgery only 14 no treatment during pregnancy 96 chemotherapy 11 radiotherapy 1:1 matched Study design

Methods General HealthCognitive outcomeHeart morphology and functions General pediatric and clinical neurological examination Bayley Scales of Infant Development – second / third edition Echocardiography General health questionnaireElectrocardiography

Perinatal outcome Median GA: 36 weeks (range 27-41) Prematurity 8,5% very preterm (27,0-31,9w) 12,4% moderate preterm (32,0-33,9w) 40,3% late preterm (34,0-36,9w) 38,8% full term (37,0-41,9w) Median birth weight: 2705g (range ) vs. 2755g ( ) in controls (P=0,502) 61,2% born preterm

Postnatal growth MalesFemales Study group Control group Weight (kg) Head circumference (cm) Length (cm)

General health Incidence of medical problems Need for surgery or medical care  comparable between study and control group

Study group Control group Cognitive outcome

Cognitive outcome and chemo cycles

X ---- Study group Control group Cognitive outcome and prematurity

Acknowledgements Fund for Cancer in Pregnancy