Exovene: Treatment of Testicular Cancer Chylee Martin and Helaina Lefler.

Slides:

Advertisements

Similar presentations

Advertisements

Modified Megestrol The Clinical Trials by : Carolina R. Akib

Clinical Trials Medical Interventions

CHAPTER 8 AN INTRODUCTION TO METABOLISM The totality of an organism’s chemical reactions is called _______________. A cell’s ______________ is an elaborate.

Chapter 6 Metabolism: Energy and Enzymes. Metabolism The totality of an organism's chemical reactions, consisting of catabolic and anabolic pathways Catabolic.

16.6 Factors Affecting Enzyme Activity

Cancer Clinical Trials: The Basics. 2 What Are Cancer Clinical Trials? Research studies involving people Try to answer scientific questions and find better.

Chapter 6: Energy and Metabolism By Samuel Mayes-Sanchez, Evan Reyes, Jordan Dallas.

Introduction Hypothesis Conclusions and Limitations Specific Aims Effects of Apple Cider Vinegar on Postprandial Glucose Levels in Adults with Type 2 Diabetes.

Rapivab™ - peramivir injection

Clinical Trials. What is a clinical trial? Clinical trials are research studies involving people Used to find better ways to prevent, detect, and treat.

PSY 853 PRESENTATION – Chapter 14 Anabolic-Androgenic Steroids.

 Since the cell cycle is known, now we must ask what controls it  Noted that healthy cells in contact will not divide ◦ Essentially, this is how our.

Testing People Scientifically.  Clinical trials are research studies in which people help doctors and researchers find ways to improve health care. Each.

Why is Patrick Paralyzed? Maureen Knabb Department of Biology West Chester University 1.

Enzymes Objectives: (a)

Enzymes. biological catalysts speed up chemical reactions without being consumed usually proteins with tertiary or quaternary structure.

Lung Cancer Emily Cauchon Katie Reeves Emily Cauchon Katie Reeves.

Introduction to Metabolism Energy & Enzymes Ms. Napolitano Honors Biology.

 Cell cycle is known, so now we ask what controls it  We have observed many factors that influence a cell’s ability to move forward in the cycle ◦ Kinetochores.

ORIGIN Outcome Reduction with an Initial Glargine Intervention (ORIGIN) Trial Overview Large international randomized controlled trial in patients with.

Chemical Reactions and Enzymes Chapter 8: An Introduction to Metabolism.

7.6 Enzymes (AHL) Pp Pp

بسم الله الرحمن الرحيم جامعة أم درمان الإسلامية كلية الطب و العلوم الصحية - قسم طب المجتمع مساق البحث العلمي / الدفعة 21 Basics of Clinical Trials.

I. Energy and the Cell A. Energy – the capacity to perform work (Bioenergetics = the study of how energy flows through living organisms) 1. Kinetic energy.

Section 3 Lesson 2– The Catalytic Cycle. What do enzymes do? Enzymes lower the activation energy E a required for a reaction to occur.

 When a person is unable to reproduce.  Both Males and Females can be sterile.  Males are unable to produce healthy sperm.  This may be due to environmental.

Treatment of CML. Goal of Therapy Complete molecular remission and cure – Achieve prolonged, durable, nonneoplastic, nonclonal hematopoiesis, – Eradication.

Ch. 8 An Introduction to Metabolism. A organism’s metabolism is subject to thermodynamic laws The totality of an organism’s chemical reactions is called.

An Introduction to Metabolism Chapter 8. n n Objectives F F Explain how the nature of energy transformations is guided by the two laws of thermodynamics.

AP BIOLOGY Chapter 8 Metabolism. The _____ Law of Thermodynamics states that energy can be transformed and transferred by NEVER created or destroyed Anabolic.

Purpose of Clinical Trials Assess safety and efficacy of Experimental treatments New combinations of drugs New approaches to surgery or radiation therapies.

INTRODUCTION TO METABOLISM. Chapter 8 Metabolism, Energy, and Life.

ENERGY AND THE CELL Cells transform energy as they perform work Cells are small units, a chemical factory, housing thousands of chemical.

5.12 Chemical reactions either release or store energy  An endergonic reaction requires an input of energy and yields products rich in potential energy.

Journal Club Leona Isabella von Köckritz.

Part 2 INHIBITION ALLOSTERIC REGULATION FEEDBACK INHIBITION.

Chapter 5: Cellular Processes Pg. 85 Enzyme Regulation Objective: I can identify and describe the different ways enzymes are regulated, based.

Angela Aziz Donnelly April 5, 2016

The process of drug development. Drug development 0,8 – 1 mld. USD.

Treatment for Cancer. Surgery Treatment and prognosis depend on severity and spread of the cancer Treatment and prognosis depend on severity and spread.

Statins The AURORA Trial Reference Fellstrom BC. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med. 2009;360. A.

Chemical Reactions & Enzymes

Eucrisa™ - Crisaborole

Enzymes Catalyst Activation Energy Substrates Enzyme Activity

By: Jake Henderson, Meagan McMahan

Clinical Trials Medical Interventions

Globular Protein Made of amino acid chains

Control of Metabolic Pathways (2)

The Impact of a Structured Balance Training Program on Elderly Adults

8 An Introduction to Metabolism.

Chapter 5: Enzymes.

دانشیار دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید صدوقی یزد

Clinical Trials.

Ethics in clinical Trial

Part 2 INHIBITION ALLOSTERIC REGULATION FEEDBACK INHIBITION

The Regeneration of ATP

Chapter 5 The Working Cell.

Protein Functions 5.3,

Metabolism and enzymes

Figure 6.1 The complexity of metabolism

Summary of chemical reactions in a cell

Unit H: Enzymes.

CHAPTER 5 The Working Cell

______ Chapter 6~ An Introduction to Metabolism.

Enzymes and Metabolism

Chapter 5 Lecture Outline See PowerPoint Image Slides

Cellular Processes and structure

Functional analysis of S6K1 regulation of apoptosis control

Presentation transcript:

Exovene: Treatment of Testicular Cancer Chylee Martin and Helaina Lefler

Population Young adult males between the ages of 18 and 40 who have been diagnosed with testicular cancer

Potential Risks and Benefits Risks Hair loss Nausea/vomiting Dizziness Lower levels of testosterone or decreased sperm levels Benefits Treatment of cancer Reduce side effects, promote tumor shrinkage, completely eradicate testicular cancer

Description of Treatment Delivery method: ointment applied directly to testicles The treatment will target cancerous cells of the testicles that have increased metabolisms The nanoparticles with competitive inhibitors for a cellular respiration enzyme will attach to and enter the cells and their mitochondria

Description of Treatment Nanoparticles with competitive inhibitors will inhibit the hexokinase enzyme that catalyzes the phosphorylation of glucose, therefore inhibiting cellular respiration and metabolism The competitive inhibitor will bind to the hexokinase active site, therefore inhibiting cellular respiration The cells will then die because they will be unable to make ATP and will not be able to survive

Trial Objectives and Purpose Goals: to determine… The efficacy of the treatment Any side effects the treatment presents Proper dosages Hypothesis: the Exovene treatment will successfully kill the cancerous cells by inhibiting cellular respiration and eradicate the testicular cancer This treatment is better than previous treatments because it can be applied directly to the affected area, will not affect any surrounding healthy cells, and will cause less discomfort for the patient.

Trial Design Double-Blind Trial One randomized group of 50 patients will receive one treatment, while the second randomized group of 50 patients will receive another treatment (based off strata of similar individuals) Treatments will randomly be assigned to each group One group receives Exovene treatment The other group receives a placebo

Selection of Subjects Criteria: Male Must be within age group (21 to 40 years old) Must be diagnosed with testicular cancer

Assessment of Safety Do not use except for the intended medical purpose Do not allow anyone else to use the ointment Use only on the patient’s testicles Do not go over or under in dosage (use with proper prescription)