How the cholera bacterium causes disease

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Presentation transcript:

How the cholera bacterium causes disease What is cholera and how do the symptoms arise? How the cholera bacterium causes disease Poor sanitation Inadequate sewage system Lack of clean water Houses lack basic facilities Crowded living conditions

What is cholera and how do the symptoms arise? Cholera bacteria are ingested by humans through faecal contaminated food or water.

What is cholera and how do the symptoms arise? Cholera bacteria penetrate mucus lining of the small intestine using their flagella.

What is cholera and how do the symptoms arise? Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.

What is cholera and how do the symptoms arise? Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.

What is cholera and how do the symptoms arise? Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.

What is cholera and how do the symptoms arise? Cholera bacteria produce a protein toxin consisting of 2 parts – one part binds to specific glycolipid receptors on the intestine wall. The second part is ingested by the cell.

What is cholera and how do the symptoms arise? The toxin starts a chain of events in the cell which result in chloride channels in the membrane opening.

What is cholera and how do the symptoms arise? The flood of chloride ions out of the cells into the lumen of the small intestine lowers the water potential. Cl- Cl- Cl- Cl- Cl- Cl- Cl-

What is cholera and how do the symptoms arise? What happens to the water potential in the small intestinal lumen? Cl- Cl- Cl- Cl- Cl- Cl- Cl-

Cholera Water floods out of cells into the small intestine by osmosis. What is cholera and how do the symptoms arise? Cholera Water floods out of cells into the small intestine by osmosis. H2O H2O H2O H2O Cl- H2O H2O H2O Cl- Cl- H2O Cl- H2O H2O Cl- H2O H2O Cl- Cl- H2O H2O H2O H2O

What is cholera and how do the symptoms arise? The increased water causes profuse watery diarrhoea. There is so much diarrhoea that the stools eventually turn into a ‘rice water’ colour.

How does the bacterium cause disease? What is cholera and how do the symptoms arise? How does the bacterium cause disease? Lumen of small intestine Toxin Cl- Cl- Chloride Channel Cl- Cl- Water