Unit6 Cell Division Mitosis and Meiosis

Cell Division A complex series of changes in the nucleus of a cell that leads to the production of two new cells. The new cells are called daughter cells.

Why do cell divide?? DNA overload- The cell’s DNA would no longer be able to serve the increasing needs of the growing cell. Exchange of Materials -If cells grow to large, its more difficult to get rid of waste and take in nutrients.

Why do cells divide? Growth- Humans start off as one cell by the time they are adults they have over 10 trillion cells. Repair- tissue damage Reproduction – Asexual or Sexual

What is inside of the Nucleus? Genetic information that is passed on from one generation of cells to the next. Chromosomes are made up of DNA Chromosomes are only visible during cell division

Chromosomes

Parts of the chromosome Centromere - the part of a chromosome that links sister chromatids Chromatid - one copy of a duplicated chromosome, which is generally joined to the other copy by a single centromere. Gene segment – segment of gene that codes for a trait

Karyotype - a photograph of a full set of chromosomes “Sex Chromosomes” …….the 23 rd set 23 This person has 2 “X” chromosomes… and is a female.

Cell Cycle Hormones send signals to cells to prepare for division when it is needed.

How do Cells divide? INTERPHASE – growth and preparation Mitosis - involves a complex series of changes in the nuclei of body cells that produce identical daughter cells

Mitosis Phases Prophase – Nuclear Membrane becomes invisible and chromosomes condense Metaphase – Chromosomes line up in the middle Anaphase – Chromosomes are pulled apart by spindle fibers that attach at the centromere Telophase – Cell plate forms, cell membrane pinches in and cytokinesis occurs

Stages of Mitosis

Cytokinesis Dividing of the Cytoplasm and the creation of two daughter cells during Telophase

The Cell Cycle and Cancer

There are several factors that regulate the cell cycle and assure a cell divides correctly. 1.Before a cell divides, the DNA is checked to make sure it has replicated correctly. (If DNA does not copy itself correctly, a gene mutation occurs.)

2. Chemical Signals tell a cell when to start and stop dividing.

3. Neighboring cells communicate with dividing cells to regulate their growth also. Cancer is a disease of the cell cycle. Some of the body’s cells divide uncontrollably and tumors form.

While normal cells will stop dividing if there is a mutation in the DNA, cancer cells will continue to divide with mutation.

Tumors in Liver

SUMMARY Normal Cell Division 1.DNA is replicated properly. 2. Chemical signals start and stop the cell cycle. 3. Cells communicate with each other so they don’t become overcrowded. Cancer Cells 1.Mutations occur in the DNA when it is replicated. 2. Chemical signals that start and stop the cell cycle are ignored. 3. Cells do not communicate with each other and tumors form.

Causes that disrupt the cell cycle Smoking tobacco Radiation exposure Viral infection –Human Papillomavirus (HPV) Chemicals

Estimated Cancer Deaths in the US in 2013

Treating Cancers Cancer treatments include drugs that can stop cancer cells from dividing.

MEIOSIS

Organisms that reproduce Sexually are made up of two different types of cells. 1.Somatic Cells are “body” cells and contain the normal number of chromosomes ….called the “Diploid” number (the symbol is 2n). Examples would be … skin cells, brain cells, etc. (Mitosis Cell Division) 2.Gametes are the “sex” cells and contain only ½ the normal number of chromosomes…. called the “Haploid” number (the symbol is n)….. Sperm cells and ova are gametes. (Meiosis Cell Division)

Meiosis Cell Division Cell division that forms of sex cells (gametes) Egg cell and Sperm cell (gametes) 4 daughter cells are made with each having half the number of chromosomes as parent cell (n) Haploid Reduction of chromosomes Cells are NOT identical to parent

Stages of Meiosis

Homologous Chromosomes chromosomesmaternalpaternalPair of chromosomes (maternal and paternal) that are similar in shape and size. (tetrads)Homologous pairs (tetrads) carry genes controlling the same inherited traits. locus(position of a gene)Each locus (position of a gene) is in the same position on homologues. homologous chromosomes.Humans have 23 pairs of homologous chromosomes. autosomes 22 pairs of autosomes sex chromosomes 1 pair of sex chromosomes

Homologous Chromosomes ( because a homologous pair consists of 4 chromatids it is called a “Tetrad”) PaternalMaternal eye color locus eye color locus hair color locus hair color locus

Crossing Over creates variation (diversity) in the offspring’s traits. nonsister chromatids variation Tetrad

Factors that Cause Genetic Variation in Offspring Crossing Over Genetic Mutation of DNA

Question: 20 chromosomes(diploid) chromosomesA cell containing 20 chromosomes (diploid) at the beginning of meiosis would, at its completion, produce cells containing how many chromosomes?

Answer: 10 chromosomes (haploid)10 chromosomes (haploid)