Automated Metered Dose Inhaler Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn

Background What is a Metered Dose Inhaler? What is a Metered Dose Inhaler? pocket-sized handheld inhaler delivers standardized dose of medication for bronchodilation Who Uses Them? Who Uses Them? Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Setting? Critical patients in hospitals Critical patients in hospitals Prescriptions for outpatient or in-home use Prescriptions for outpatient or in-home use

Problem Definition Automatic Metered Dose Inhalant (MDI) delivery device: Automatic Metered Dose Inhalant (MDI) delivery device: Electromechanical, in-hospital inhalant drug delivery system Electromechanical, in-hospital inhalant drug delivery system Patients are mechanically ventilated and sedated Patients are mechanically ventilated and sedated Medication delivered automatically as prescribed electronically Medication delivered automatically as prescribed electronically Medication must be well shaken (homogenized with propellant) Medication must be well shaken (homogenized with propellant)

Design Factors Integration with existing endotracheal tubing Integration with existing endotracheal tubing Homogenization with propellant Homogenization with propellant Delivery of medication into ventilation system Delivery of medication into ventilation system Tubing length Tubing length Synchronization of delivery with breathing Synchronization of delivery with breathing Software/Automation Software/Automation User interface User interface Prescription error checking Prescription error checking

Project Status Preliminary Research Complete Standard MDI Completed Research Endotracheal Tubing Connectors Ventilators (Siemens Servo I) Types of Medication Continuing Research Homogenizer

Working Design: Using Prefabricated Canisters Integrated with existing tubing Integrated with existing tubing In-line using AeroVent CHC In-line using AeroVent CHC Homogenize Homogenize Vortexer Vortexer Phone Vibrator Phone Vibrator Spring-Loaded Agitator  Spring-Loaded Agitator  Actuator Actuator Laptop-based prescription entry Laptop-based prescription entry Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump

Shaking = Homogenization Key obstacle - homogenization Key obstacle - homogenization Actuator - homogenize and administer Albuterol Actuator - homogenize and administer Albuterol Solenoid Solenoid Simple singular directional motion Simple singular directional motion Small yet powerful Small yet powerful

Timeline Completed Work Completed Work Preliminary research Preliminary research Clearly defined design factors Clearly defined design factors Through Innovation Workbench Through Innovation Workbench Current Work Current Work Order more components to start building prototype Order more components to start building prototype Actuator (solenoid), Vibrator, AnaConDa™ Actuator (solenoid), Vibrator, AnaConDa™ Testing distance were adequate dose is still administered through tubing Testing distance were adequate dose is still administered through tubing Building Model A Building Model A Timeline Testing using Albuterol (Anna Ambrose) Meeting with Kevin Seale Friday, 2/6/04 Testing ~ Third week of February Implement corrections Model B ~ Second week of March Software included Testing ~ End of March Final prototype ~ April

References bkgd.shtml bkgd.shtml bkgd.shtml bkgd.shtml ry/anesthesia_glossary-05.htm ry/anesthesia_glossary-05.htm ry/anesthesia_glossary-05.htm ry/anesthesia_glossary-05.htm ent.asp?page=5 ent.asp?page=5 ent.asp?page=5 ent.asp?page=5 Hudson RCI. AnaConDa™ Principles of Operation Hudson RCI. AnaConDa™ Principles of Operation. 2003