ICC_MAN (n=3385 total processed MRI with M status ): min max mean median std range 25 quartile 50 quartile 75 quartile

ICC_MAN (n=2746 total CLIMB): min max mean median std range quartile quartile quartile

ICC_MAN (n=2032 CLIMB with track period): min max mean median std range quartile quartile quartile

ICC_MAN (n=2032 CLIMB with track period):

ICC_MAN (n=2032 CLIMB with track period) TP'0''12''24''36''48''60''72''84''96''108''120' N MEANS s ( StdErr)

ICC_MAN (n=923 CLIMB with track period) 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 1 timepoint 482 with 2, 3, with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints ICC_MAN (1590 tp n=482 CLIMB longitudinals with track period)

ICC_MAN_l (1590 tp n=482 CLIMB longitudinals with track period) Prediction plot

ICC_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

CSF_MAN (2746 total) : min53.34 max mean median std range quartile quartile quartile

CSF_MAN (2032 with track period ): min54.91 max mean median std range quartile quartile quartile

CSF_MAN (2032 with track period) TP0'12'24'36'48'60'72'84'96'108'120' N MEANS StdErr

CSF_MAN (n=923 longitudinal CLIMB with track period), 442 with 1 timepoint 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 1 timepoint 482 with 2, 3, with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

CSF_MAN (n=923 longitudinal CLIMB with track period) 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 2, 3, with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints

BPF_MAN (2746 total) : min max mean median0.857 std range quartile quartile quartile

BPF_MAN (2032 with CLIMB track period): min max mean median0.846 std0.051 range quartile quartile quartile 0.798

BPF_MAN (2032 with track period) TP0'12'24'36'48'60'72'84'96'108'120' N m s

BPF_MAN (2032 MRI n=923 patients longitudinal CLIMB with track period) 442 with 1 tp 482 with multiple tps 234 with 2 tps 76 with 3 tps 57 with 4 tps 53 with 5 tps 41 with 6 tps 14 with 7 tps 6 with 8 tps 1 with 9 tps 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope'

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints BPF_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

Individual Prediction plots

BPF_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

min0.2 max88.78 mean median3.59 std9 range quartile quartile quartile 8.15 T2_MAN (2745 total) :

T2_MAN_climb (2032 with CLIMB track period): min0.2 max88.78 mean6.825 median3.465 std range quartile quartile quartile 8.135

TP0'12'24'36'48'60'72'84'96'108'120' N m s T2_MAN_l (2032 with track period)

T2_MAN (2032 MRI n=923 patients longitudinal CLIMB with track period) 442 with 1 tp 482 with multiple tps 234 with 2 tps 76 with 3 tps 57 with 4 tps 53 with 5 tps 41 with 6 tps 14 with 7 tps 6 with 8 tps 1 with 9 tps 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope'

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' with 2 timepoints 76 with 3 timepoints 57 with 4 timepoints 53 with 5 timepoints 41 with 6 timepoints 14 with 7 timepoints 6 with 8 timepoints 1 with 9 timepoints T2_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

Individual Prediction plots

T2_MAN_l (1590 tp n=482 CLIMB longitudinals with track period)

7365 (2002) (2003) month (2011)33812 (2012) CLIMB dataset with track period 9 timepointsAvailable processed MRI Longitudinal dataset

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' ICC longitudinal (1 dataset with 9 timepoints):

BPF longitudinal (1 dataset with 9 timepoints): 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope'

T2 longitudinal (1 dataset with 9 timepoints): 'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope'

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' ICC longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' BPF longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

'Term''Estimate''Std. Err.''T''Prob>|T|' 'Intercept' 'Slope' T2 longitudinal (7 cases: 6 dataset with 8 timepoints and 1 dataset with 8 timepoints from dataset with 9 timepoints):

Dendrogram or hierarchical cluster tree X=[T2LV_MAN,BPF_MAN] Standardized Euclidean distance. Each coordinate in the sum of squares is inverse weighted by the sample variance of that coordinate. Linkage with inner squared distance (minimum variance algorithm)

Dendrogram or hierarchical cluster tree X=[T2LV_MAN,BPF_MAN] Mahalanobis distance. Each coordinate in the sum of squares is inverse weighted by the sample variance of that coordinate. Linkage with inner squared distance (minimum variance algorithm)

Plot Manova1 matrixManovacluster(stats) X=[Timepoint, BPF, T2, ICC]

Canonical analysis