Chapter 40 The Immune System and Disease
40-2 The Immune System Immunity – The process of fighting against infection through the production of cells that inactivate foreign substances or cells. Nonspecific Defenses First line of defense – Function is to keep pathogens out of the body. skin, mucus, sweat, and tears Second line of defense – Function is to destroy pathogens that enter the body. Inflammatory response—nonspecific disease reaction to tissue damage Fever—Elevated body temperature that slows down or stops the growth of pathogens.
Specific Defenses Immune response – A series of specific defenses that attack the invading pathogens. Antigen – substance that triggers an immune response Viruses, Bacteria, and other pathogens Humoral Immunity Antibodies – proteins that recognize and bind to antigens (pg. 1038). Produced by B Cells, also called Plasma Cells. Cell-Mediated immunity Body’s defense against its own cells that have become cancerous or infected with viruses. B cells (lymphocytes) – provide immunity against pathogens in body fluids (Humoral Immunity) T cells (lymphocytes) – provide defense against pathogens in living cells (Cell-Mediated Immunity)
Types of T cells Killer T - track and destroy invaders Helper T – create memory T cells Suppressor T – release substances that shut down killer T cells Memory T – cause secondary response if the same antigen enters the body again at a later time
Acquired Immunity Active immunity— Appears after exposure to an antigen. Vaccination—The injection of a weakened or mild form of a pathogen to produce immunity. Natural exposure—Fighting an infection. Passive Immunity – Antibodies produced by other animals against a pathogen are injected into the bloodstream. Lasts only a short time. Mother to Child—Through breast milk or across the placenta. Administration of Antibodies—Used to treat people who have a disease or are travelling to where a disease is prevalent. Example: vaccine that contains antibodies like rabies vaccine
40-3 Immune System Disorders Allergies – allergens (antigens) – attach to the mast cells, which induce inflammatory response. Histamines – activated mast cells release histamines, which increase blood flow to surrounding area. Asthma – respiratory disease often caused by allergies. Autoimmune Disease – immune system makes a mistake and causes the body to attack its own cells. Type I Diabetes, Multiple Sclerosis, Rheumatoid Arthritis
HIV and AIDS Viral infection that destroys helper T cells, causing the normal immune response to break down. HIV retrovirus – Carries genetic information in RNA instead of DNA. Page 1046 – shows infection of HIV.