The Cell Cycle Year 12 Biology C9

Draw a circle to the left hand side of the page

Divide the circle into four sections

Divide the right- hand quarter into fourths.

Label the quarters G1 Phase S Phase G2 Phase M PhaseM Phase M PhaseM Phase

Label the phases of M-phase (Mitosis) G1 Phase S Phase G2 Phase M PhaseM Phase M PhaseM Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of mitosis. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase

Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles

Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis

Add details of each phase of the cell cycle G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Damage Cell big enough?

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Check for DNA Damage Cell big enough?

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Check for DNA Damage Cell big enough?

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Hold to break down cyclins Check for DNA Damage Cell big enough?

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Pause to break down cyclins Check for DNA Damage Cell big enough?

Add checkpoints G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Check for DNA Synthesis Cell size Pause to break down cyclins Check for DNA Damage Cell big enough?

Add external growth factors… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus

Nucleus makes internal regulators.. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus Kinase Cyclin

Nucleus makes internal regulators.. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Mitosis promoting factor (e.g. hormone) Nucleus CDK complex

CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs build up… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs start to break down… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

CDKs start to break down… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex

Only when all CDK has broken down can the cell proceed to Metaphase… G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy

G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy Only when all CDK has broken down can the cell proceed to Metaphase…

G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy G0 phase At telophase the cell can go into G0 phase (and remain there) or continue on to the cell cycle…

G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy G0 phase Differentiation The cell may then become differentiated into any one of the 200 body cells in humans..

Role of inhibitors… p27blocks the build up of CDK complex during G1 and prevents movement to S phase G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex p27

Role of inhibitors… p27blocks the build up of CDK complex during G1 and prevents movement to S phase p53 stops cell cycle at any point if DNA is damaged. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex p53

Role of inhibitors… If mutations occur to inhibitors – cancer may result i.e. uncontrolled cell cycle. G1 Phase S Phase G2 Phase Prophase Metaphase Anaphase Telophase Cell growth Energy Organelles DNA Synthesis Cell Growth Energy CDK complex