Haptoglobin 1-1 Genotype is Associated With Poorer Cognitive Functioning in the Elderly With Type 2 Diabetes Featured Article: Ramit Ravona-Springer, M.D.,

Slides:

Advertisements

Similar presentations

Methods for Studies in Preventing Cognitive Loss and Dementia

Advertisements

Reductions in Regimen Distress Are Associated With Improved Management and Glycemic Control Over Time Featured Article: Danielle Hessler, Lawrence Fisher,

THE DIABETES PREVENTION PROGRAM RESEARCH GROUP*

Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society Featured Article: Elizabeth R. Seaquist,

Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): Urinary Screening and Baseline Biochemical and Cardiovascular Assessments Featured.

Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity Featured Article: Ricardo V. Cohen, M.D., Jose C. Pinheiro, M.D.,

Factors Associated With Weight Gain in People With Type 2 Diabetes Starting on Insulin Featured Article: Beverley Balkau, Philip D. Home, Maya Vincent,

Significance of White Matter Hyperintensities in MCI Charles DeCarli University of California at Davis Alzheimer’s Disease Center Imaging of Dementia and.

Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden Featured Article: Tom W.C. Lung, Dennis Petrie, William.

The Effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for Patients With Diabetes and Subclinical Depression: Results of a Randomized.

Vitamin D Levels Predict All-Cause and Cardiovascular Disease Mortality in Subjects With the Metabolic Syndrome Featured Article: G. Neil Thomas, Ph.D.,

Both Dietary Protein and Fat Increase Postprandial Glucose Excursions in Children With Type 1 Diabetes, and the Effect Is Additive Featured Article: Carmel.

Cystatin C– and Creatinine-Based Estimated Glomerular Filtration Rate, Vascular Disease, and Mortality in Persons With Diabetes in the U.S. Featured Article:

Individualizing Targets and Tactics for High- Risk Patients With Type 2 Diabetes Practical lessons from ACCORD and other cardiovascular trials Featured.

Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes A double-tracer study.

Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes Featured Article: Pascaline Priou,

Follow Up Questions Diabetes is caused by an increase in blood glucose. People with diabetes II also have a very high risk for developing Alzheimer’s disease.

Metabolic Syndrome and Risk of Cancer: A Systematic Review and Meta-Analysis Featured Article: Katherine Esposito, M.D., Ph.D., Paolo Chiodini, Ph.D.,

The Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth.

Brain Atrophy in Type 2 Diabetes Regional distribution and influence on cognition Featured Article: Chris Moran, M.B., B.C.H., Thanh G. Phan, P.H.D., Jian.

The Cross-sectional and Longitudinal Associations of Diabetic Retinopathy With Cognitive Function and Brain MRI Findings: The Action to Control Cardiovascular.

The Hyperglycemia and Adverse Pregnancy Outcome Study

The Relationship of Urologic Complications With Health- Related Quality of Life and Perceived Value of Health in Men and Women with Type 1 Diabetes: The.

Early Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes Featured Article: Aris Siafarikas, F.R.A.C.P., M.D., Robert J.

Peripheral and Central Nervous System Drugs Advisory Committee Meeting - March 14, Issues Related to the Development of Drugs for the Treatment.

Risk of Dementia in Seniors with Newly Diagnosed Diabetes: A Population-Based Study Featured Article: Nisha Nigil Haroon, Peter C. Austin, Baiju R. Shah,

Retinal Vascular Geometry Predicts Incident Renal Dysfunction in Young People with Type 1 Diabetes Featured Article: Paul Z. Benitez-Aguirre, M.P.H., FRACP.,

Risk Factors for Decline in IQ in Youth With Type 1 Diabetes Over the 12 Years From Diagnosis/Illness Onset Featured Article: Ashleigh Lin, Elisabeth A.

Microstructural White Matter Abnormalities and Cognitive Functioning in Type 2 Diabetes A Diffusion Tensor Imaging Study Featured Article: Yael D. Reijmer,

Long-Term Complications and Mortality in Young-Onset Diabetes Type 2 diabetes is more hazardous and lethal than type 1 diabetes Featured Article: Maria.

Retinopathy in Youth With Type 2 Diabetes Participating in the TODAY Clinical Trial Featured Article: TODAY Study Group* Diabetes Care Volume 36:

Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults Featured Article: Peter T. Campbell, Ph.D., Christina C. Newton,

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention The POUNDS LOST trial Featured Article: Qibin.

Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth.

Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men: A Randomized Controlled Trial Featured Article: Isabelle Aeberli,

Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes Featured Article: Christie Y. Jeon, Sc.D., Mary N. Haan, Dr.PH., Caroline.

Evaluation of Current Eligibility Criteria for Bariatric Surgery Diabetes prevention and risk factor changes in the Swedish Obese Subjects (SOS) study.

Clinical and Economic Benefits Associated With the Achievement of Both HbA1c and LDL Cholesterol Goals in Veterans With Type 2 Diabetes Featured Article:

Childhood and Adult Secondhand Smoke and Type 2 Diabetes in Women Featured Article: Martin Lajous, M.D., S.C.D., Laura Tondeur, M.S., Guy Fagherazzi, P.H.D.,

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome Featured Article: Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet.

Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function Featured Article: Elif I. Ekinci, P.H.D.,

Prognostic Accuracy of Immunologic and Metabolic Markers for Type 1 Diabetes in a High-Risk Population: Receiver Operating Characteristic Analysis Featured.

Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006 Featured Article: Edward W. Gregg, Ph.D., Yiling J. Cheng, Ph.D.,

Mortality After Incident Cancer in People With and Without Type 2 Diabetes Featured Article: Craig J. Currie, Ph.D., Chris D. Poole, Ph.D., Sara Jenkins-Jones,

Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future.

Serum Concentration of Cystatin C and Risk of End-Stage Renal Disease in Diabetes Featured Article: Andrzej S. Krolewski, M.D., Ph.D., James H. Warram,

Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity Featured Article: Ania M. Jastreboff, Cheryl.

High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Featured.

Short- and Long-Term Mortality After Myocardial Infarction in Patients With and Without Diabetes Featured Article: Sjoerd T. Nauta, M.S.C., Jaap W. Deckers,

Trends in Diabetes Incidence: The Framingham Heart Study Featured Article: Tobin M. Abraham, Karol M. Pencina, Michael J. Pencina, and Caroline S. Fox.

Risk Factors Associated With Severe Hypoglycemia in Older Adults With Type 1 Diabetes Featured Article: Ruth S. Weinstock, Stephanie N. DuBose, Richard.

Journal Club Julie Shah, MD Milton S Hershey Medical Center Penn State University.

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of.

Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study Featured Article: Matthew Kurien, Kaziwe Mollazadegan,

DIABETES AS A RISK FACTOR FOR COGNITIVE DECLINE IN OLDER PATIENTS F. Limongi, A. Marseglia, S. Maggi, M. Noale, G. Romanato, P. Siviero, G. Crepaldi CNR,

Association of Body Mass Index (BMI) and Depression Severity

Priming of Landmarks During Object-Location Tasks:

The Relationship Between Mental and Physical Health

TIA for the Internist The American Journal of Medicine

Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study Prof Daniel Kotz, PhD, Wolfgang Viechtbauer, PhD, Colin Simpson,

Rebecca L. Hoffman, MD, Rachel R. Kelz, MD, FACS, Christopher J

In the Literature: Cognitive Impairment in Hemodialysis Patients

Research and research funding in vascular surgery

Participant flow diagram for the ‘GNHIES98—longitudinal sample’ and the ‘DEGS1—cross-sectional sample’. Participant flow diagram for the ‘GNHIES98—longitudinal.

Tissue (muscle) oxygen saturation (StO2): A new measure of symptomatic lower- extremity arterial disease Anthony J Comerota, MD, Richard C Throm, BA,

Associations of olfactory brain activation and functional connectivity with neuropsychological test scores and diabetic parameters. Associations of olfactory.

SDF-1, adiponectin, and sVCAM levels are higher in Medalists than controls, but SDF-1 does not differ with respect to vascular complications; PAI-1 and.

Diabetes in Young Adults

The risk for incident cognitive dysfunction after an episode of severe (A) or nonsevere (B) hypoglycemia with and without accounting for the competing.

WM volume did not show the expected increase in volume with age in children with type 1 diabetes (●), in contrast with HC subjects (▲) who showed the (expected)

Presentation transcript:

Haptoglobin 1-1 Genotype is Associated With Poorer Cognitive Functioning in the Elderly With Type 2 Diabetes Featured Article: Ramit Ravona-Springer, M.D., Anthony Heymann, M.D., James Schmeidler, P.H.D., Elizabeth Guerrero-Berroa, P.H.D., Mary Sano, P.H.D., Rachel Preiss, B.A., Keren Koifman, B.A., Hadas Hoffman, B.A., Andrew Levy, M.D., Jeremy M. Silverman, P.H.D., Michal Schnaider-Beeri Diabetes Care Volume 36: October, 2013

STUDY OBJECTIVE Haptoglobin (Hp) genotype (Hp 1-1, 1-2, or 2-2) is associated with risk for type 2 diabetes complications Its relationship with cognitive compromise is rarely studied We studied whether Hp genotype is associated with cognitive function in cognitively normal elderly diabetic subjects Ravona-Springer R. et al. Diabetes Care 2013;36:

STUDY DESIGN AND METHODS Relationships of Hp genotype with episodic memory, semantic categorization, attention/working memory and executive function, and an overall cognitive score were examined Subjects were from the Israel Diabetes and Cognitive Decline (IDCD) study Ravona-Springer R. et al. Diabetes Care 2013;36:

RESULTS 812 subjects participated (84 with Hp 1-1, 335 with Hp 1-2, and 393 with Hp 2-2 genotypes) Compared with Hp 1-2 and Hp 2-2 genotype subjects, Hp 1- 1 subjects performed significantly worse in semantic categorization and the overall cognitive score Contribution of cardiovascular risk factors to cognition was significantly higher in subjects with the Hp 1-1 genotype compared with the Hp 1-2 and Hp 2-2 genotypes in the semantic categorization and attention/working memory cognitive domains Ravona-Springer R. et al. Diabetes Care 2013;36:

CONCLUSIONS Compared with Hp 2 carriers, individuals with the Hp 1-1 genotype present lower cognitive performance Stronger relationships between cardiovascular risk factors and cognition in the latter group may suggest an underlying vascular mechanism Ravona-Springer R. et al. Diabetes Care 2013;36: