HeC PMT Meeting Tallinn 10 July 2008 Brainstorming session: what interest can there be in thinking about a possible new HeC 2 project to follow-up the current one, after its end by 2009 Edwin Morley-Fletcher, Lynkeus

2Health-e-Child, July 10 th, ICT Work Programme Structure: A limited set of Challenges Each of which is addressed through a limited set of Objectives That form the basis of Calls for Proposals A total of 25 Objectives expressed within 7 Challenges

3Health-e-Child, July 10 th, Focus on application-led challenges New technology-based systems, products and services that provide step-changes in the capabilities of the resulting application solution Evolution and interoperability of service platforms Scale and complexity in dynamic, distributed heterogeneous environments, including open service networks Advanced user-driven open innovation methodologies integrating all relevant actors in a flexible service and technology innovation ecosystem Standardisation, recognised as important research outcome and as visible way to promote research results

4Health-e-Child, July 10 th, Focus on ICT tools for sustainable and personalised healthcare Ensuring delivery of quality healthcare at affordable costs contributing to greater efficiency of health systems Saving lives and resources by focusing on: prevention and prediction of diseases improved patient safety by optimising medical interventions and preventing errors Developing new ICT-based environments for biomedical research and predictive medicine that push the boundaries of technologies like grid computing, modelling and simulation

5Health-e-Child, July 10 th, Challenge 5: Towards sustainable and personalised healthcare Looking for changes in the way healthcare is delivered and the way medical knowledge is managed and transferred to clinical practice Recent capabilities of modelling, simulation and biomedical imaging, combined with the latest knowledge about diseases, give rise to a new generation of predictive medicine In this challenge, support will go to highly interdisciplinary research

6Health-e-Child, July 10 th, Two Objectives within the ICT Work Programme Objective ICT for Patient Safety (within Call 4) Objective Virtual Physiological Human (within Call 6)

7Health-e-Child, July 10 th, Objective ICT for Patient Safety b) ICT for integration of clinical research and clinical care Seamless, secure and consistent integration of clinical care information in electronic health records (EHR) with information in clinical research information systems Research focusing on areas improving semantic interoperability between EHR and clinical research systems Definition and validation of core data set enabling scalable and standardised link between clinical research systems and EHR repositories Leading to well defined use cases with high potential for improving patient safety Possible budget distribution for a) and b): IP/STREP – around 30 M€ The objective is to support at least 1 IP under a) and at least 1 IP under b) in addition to STREPs

8Health-e-Child, July 10 th, Objective Virtual Physiological Human (1) a)Development of patient-specific computer based models and simulation of the physiology of human organs and pathologies The models should be multiscale by integrating relevant aspects of anatomy and physiology across different levels (from molecular and cellular to tissue and organ levels) The emphasis should be on the integration of existing models rather than on development of new models. The use and benefits of the models must be demonstrated for a specific clinical need covering prediction of disease and/or early diagnosis Any organ or pathology could be targeted as clinical application. If an initial phase of basic clinical research or data collection is needed it will represent less than 25% of the total effort

9Health-e-Child, July 10 th, Objective Virtual Physiological Human (2) b) Development of ICT tools, services and specialised infrastructure for the bio-medical researchers to support at least two of the following three activities: i) to share data and knowledge needed for a new integrative research approach in medicine (biomedical informatics), ii) to share or jointly develop multiscale models and simulators, iii) to create collaborative environments supporting this highly multidisciplinary field. When necessary, computing power and data management could be sought through access to existing advanced grid New tools, services and applications will also be evaluated on their effectiveness and their ability to interface with existing medical research infrastructures. Their targeted services will facilitate the clinical use of computer based organ and disease models as well as biomedical data These tools and services will complement and be compatible with existing methods and standards (terminologies, ontologies, mark-up languages) International Cooperation in this field is encouraged.

10Health-e-Child, July 10 th, Objective Virtual Physiological Human (3) Possible budget distribution for a) and b) IP/STREP – around 60 M€ with more than 50% to IPs with a minimum of 3 IPs including at least one under a) and at least one under b)

11Health-e-Child, July 10 th, HeC’s new possible goals Establishing itself as the paediatric platform by: Broadening and deepening its clinical scope Multiplying the number of paediatric hospitals being active members of HeC Increasing its overall technological integration by moving from being a SOA to becoming a SOKU

12Health-e-Child, July 10 th, Specifically with reference to call 4 Establishing HeC as the paediatric paltform also by: Assuring advanced risk-management and improved patient safety by checking internal hospital communication, appropriateness of procedures and prescriptions according to clinical indicators, and by making use of specific DSS tools Anticipating the development of EHR within paediatric hospitals by establishing common standards of electronic data input and data retrieval on HeC’s Grid platform

13Health-e-Child, July 10 th, What does SOKU mean? The evolution of Grid from a tool to solve compute- and data-intensive problems towards a general- purpose infrastructure enabling complex business processes and work flows across virtual organisations spanning multiple administrative domains Three complementary dimensions: an end-user perspective (simplicity of access to and use of Grid technologies) an architectural perspective (where the Grid is seen as a large evolutionary system made of billions of interconnected nodes of any type) a software perspective (a fully programmable and customisable Grid)

14Health-e-Child, July 10 th, David Manset’s SOKU flower

15Health-e-Child, July 10 th, Getting ready for Call 4? Advantages of: Submitting a proposal for Call 4 (Patient safety), keeping open the default solution of submitting also a proposal for Call 6 (Virtual Physiological Human ) a year later, if unsuccessful in the first attempt Starting in time a complex decision-making process within HeC, and getting appropriate feed-back from the ICT for Health Unit of the EC, which seems willing to support HeC’s further development

16Health-e-Child, July 10 th, When to communicate with ICT for Health Unit? Need to express appropriate interests in the specific definition of Call 4 Tight timing: Any expression of interest should be signaled in the coming weeks The Call is due to be issued by the Fall of 2008 The deadline for submission will be in Spring 2009 April If successful, funding could then start in 2010

17Health-e-Child, July 10 th, What specific clinical and technological developments should we focus on? Giacomo Martin