Training Translators for Smart Drug Discovery by Carsten Skarke, and Garret A. FitzGerald Sci Transl Med Volume 2(26):26cm12-26cm12 April 7, 2010 Published.

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Training Translators for Smart Drug Discovery by Carsten Skarke, and Garret A. FitzGerald Sci Transl Med Volume 2(26):26cm12-26cm12 April 7, 2010 Published by AAAS

Fig. 1. Physician-scientists at the helm. This case study demonstrates the scope of interactions involved in the pursuit of two mechanistic investigator-initiated protocols (clinicaltrials.gov identifiers NCT and NCT ). Carsten Skarke and Garret A. FitzGerald Sci Transl Med 2010;2:26cm12 Published by AAAS

Fig. 2. Modular, dis-integrated models of drug discovery and development. (Upper panel) Traditionally, the vertically integrated large pharmaceutical company retained expertise in target identification, medicinal chemistry, and clarification of the drugability of the target; pharmacokinetics and modeling; proof of concept (POC) in cells and model systems; and all phases Carsten Skarke and Garret A. FitzGerald Sci Transl Med 2010;2:26cm12 Published by AAAS