Pathology 430/826 The Molecular Basis of Disease

Path 430/ credits Course Coordinator David Lillicrap Room 201G Richardson Laboratory

PATH 430/826 Course Teaching Assistant Alison Michels

Monday 8.30 – am Room 101 Richardson Laboratory Will need to start at 8.35 am

Course Format 5 Human Disease Themes Blood malignancy Bleeding diseases Thrombotic diseases Neurological disorders Urological cancer

Course Instructors Dr. David LillicrapCoordinator/Anemia/Thrombosis/ Bleeding diseases Dr. Laura SwystunBleeding diseases/Thrombosis Dr. Michael Rauh Blood malignancies Dr. David GoodBlood malignancies Dr. Harriet FeilotterNeurologic disease Dr. John RossiterNeurologic disease Dr. David BermanUrological Cancer

Human Disease Themes 1. Common and rare 2. Inherited and acquired 3. Malignant and benign 4. Different organ systems

Course Objectives 1.To understand the molecular basis of a group of “model” human diseases (molecular pathogenesis). 2.To gain insights into diagnostic and therapeutic strategies for human disease.

Human Disease Pathology/Pathogenesis Diagnosis of Disease Treatment of Disease Central Place of Disease Mechanisms

Human Pathology - Disease Genetics ImmunologyBiochemistry Molecular biologyHistology Microbiology Diagnosis and Therapy

Week 1 1. Introduction to Path /Evaluations/Expectations 2. Introduction to Molecular Medicine/Personalized Medicine 3. A highly prevalent inherited disease – Thalassemia

Week 2 Introductory background to blood malignancies Lymphoma/leukemia ~40 mins - Then 10 min break Student Presentation #1 20 mins + 15 mins discussion/questions

Week 3 2 X 20 minute students presentations ~15 mins discussion/questions per presentation Leukemia/Lymphoma - introductory presentation (~30 mins)

Evaluative Components Path 430 and Path oral presentation30% 1 Term paper50% Course Participation 20% No mid-term or final exam

Term Paper Choice and Format 5 paper titles will be distributed just before Reading Week 10 pages – double spaced, not including figures/references Include at least 1 figure and 15 references Return by Monday April 4 th 2016 at 4pm. Path 430

Term Paper Choice and Format 1 paper title will be available by Reading Week 12 pages – double spaced, not including figures/references Include at least 2 figures and 25 references Return by Tuesday April 4 th 2016 at 4pm. Path 826

Student Presentations No longer than 20 mins No more than 30 slides Focus on Brief background Study objectives Overall study results Study conclusions Any study limitations/weaknesses Do not get distracted/confused by the minutia of results Better to present a clear representative example from the data - ie. several illustrative graphs or figures

Course Participation Expectation that everyone in class has read some of the assigned papers, and can ask relevant questions about the work. Each week, every student will be expected to hand to the Course TA, 2 questions pertinent to the papers being presented. Two or three of these questions will be asked during the class. In addition, for each paper presentation, two students will be asked at random (everyone will be asked equally over the term) to either comment on a weakness of the work, or to ask the presenter a question.

Course Expectations 1.Possession of a good background knowledge of the biological sciences 2.Show an interest in furthering this knowledge 3.Class involvement – interest in discussion responses to questions 4.Demonstrate the ability to communicate scientific knowledge, both orally and in writing, in a clear, precise and succinct manner.