SS-1 Novartis Initiatives Dear Doctor letter (Sept 2004) –Mailed to AMA list (Hem, Onc, Hem/Onc) –ADA list of oral surgeons –All urology offices purchasing Zometa ® Rolled out patient brochure addressing oral health and ONJ Updated fair balance statement to include ONJ in all promotional materials Dear Doctor letter (Sept 2004) –Mailed to AMA list (Hem, Onc, Hem/Onc) –ADA list of oral surgeons –All urology offices purchasing Zometa ® Rolled out patient brochure addressing oral health and ONJ Updated fair balance statement to include ONJ in all promotional materials (NS22-11) Med Services ONJ.ppt slide 1

SS-2 Patient Outreach Regarding Osteonecrosis of the Jaw Patient advocacy group meetings (May 2004) –9 groups representing multiple tumor types (breast, myeloma, prostate, lung, and kidney, leukemia, lymphoma) –Additional follow-up to 14 advocacy groups (Dec 2004/early 2005) Planned activity: post ODAC briefing teleconference with patient advocacy groups Patient advocacy group meetings (May 2004) –9 groups representing multiple tumor types (breast, myeloma, prostate, lung, and kidney, leukemia, lymphoma) –Additional follow-up to 14 advocacy groups (Dec 2004/early 2005) Planned activity: post ODAC briefing teleconference with patient advocacy groups (NS22-18) Patient Advocacy ONJ.ppt slide 2

SS-3 Patient Brochure (NS21-1) “Taking Care of Yourself While Living With Cancer: Dental Health and Osteonecrosis of the Jaw” Novartis Patient Information Brochure

SS-4 Novartis Initiatives—Patient Education

SS-5 ONJ White Paper (NS21-1) “Taking Care of Yourself While Living With Cancer: Dental Health and Osteonecrosis of the Jaw” Novartis Patient Information Brochure