Fig. S1 Fig. S1. Experimental design of DSS-induced colitis (A) and AOM/DSS-induced colon carcinogenesis (B).

Slides:

Advertisements

Similar presentations

Supplement Figure 1 Pharmacokinetic profile of PF was evaluated in nude mice. Mice were treated with 1 and 10 mg/kg PF via sc and iv.

Advertisements

Supplemental Fig. 1: Characteristics of T cell activation and killing induced by HER2-TDB A) T cell activation was detected at various timepoints by staining.

Supplemental data Fig. S1 Figure S1 Circulation bilirubin levels in CRC patients and non-tumor patients. Circulation bilirubin levels in CRC patients were.

Supplementary Figure 1. The effect of 17-DMAG on the growth of lung cancer cells with Met amplification Tumor cells were continuously treated with increasing.

Camacho et al, Fig. S1 a c e b d f

Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration- resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo

Δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy Akira Shibata, Kiyotaka.

Cell Physiol Biochem 2013;32: DOI: /

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

A. B. BxPC-3 PANC h h h h h 100 *** * 72 h Cell viability (%) 80 *** *** Cell viability (%) 80 *** *** 60 *** ***

Drug concentration (μM)

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

Volume 5, Issue 3, Pages (March 2004)

Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-β Against Choriocarcinoma in Xenografted.

Arctigenin inhibits prostate tumor cell growth in vitro and in vivo

Xuesong Wu, Timothy W. Wang, George M

Figure SI14. Distribution of compound 1 along with tumor blood vessels

Volume 11, Issue 2, Pages (February 2005)

Volume 19, Issue 3, Pages (March 2017)

Recombinant mumps virus as a cancer therapeutic agent

Volume 15, Issue 12, Pages (December 2007)

BV6 increases tumor burden in bone.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer Tadaaki Yamada, MD, PhD, Shinji Takeuchi,

Xuesong Wu, Timothy W. Wang, George M

DQ661 improves survival in colon cancer model and potentiates activity of gemcitabine in KPC pancreatic cancer syngeneic model. DQ661 improves survival.

Level of EGFR inhibition determines cell death response in EGFR mutant GBM cells. Level of EGFR inhibition determines cell death response in EGFR mutant.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.

Preliminary In Vivo Experimental Evidence on Intratumoral Morphine Uptake. Possible Clinical Implications in Cancer Pain and Opioid Responsiveness Edoardo.

Volume 133, Issue 4, Pages (October 2007)

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Cisplatin augments cytotoxic T-lymphocyte–mediated antitumor immunity in poorly immunogenic murine lung cancer Robert E Merritt, MD, Ali Mahtabifard,

Nicholas D. James, Jim W. Growcott European Urology Supplements

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Volume 122, Issue 2, Pages (February 2002)

Figure 1. The activity of CD26/DPP4 in patient samples with lung adenocarcinoma. The measured activity is presented by ... Figure 1. The activity of CD26/DPP4.

Thomas S. Griffith, Elizabeth L. Broghammer Molecular Therapy

Ajay Gautam, Charles L. Densmore, J.Clifford Waldrep Molecular Therapy

Volume 6, Issue 3, Pages (September 2002)

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

Effect of MI-773 dosing on long-term efficacy.

A B C D E control CORM-2 (10mM) iCORM (10mM) L-NAME (500mM)

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Abhijit De, Xiaoman Zhou Lewis, Sanjiv Sam Gambhir Molecular Therapy

Expression of p110γ isoform in macrophages promotes tumor growth and angiogenesis. Expression of p110γ isoform in macrophages promotes tumor growth and.

Antitumor efficacy of PI3K inhibitor NVP-BKM120 alone and in combination with olaparib. Antitumor efficacy of PI3K inhibitor NVP-BKM120 alone and in combination.

Volume 20, Issue 4, Pages (April 2012)

Fig. 2 In situ vaccination of CpG in combination with anti-OX40 antibody cures established local and distant tumors. In situ vaccination of CpG in combination.

NSG mice transplanted with human primary ALK-positive ALCL tumor grafts were administered either doxorubicin, 10 mg/kg i.v. or CEP orally, 100 mg/kg,

Active AR signaling in enzalutamide-resistant xenograft tumors.

Effect of therapy with S247 on the development of liver metastases after 14 and 21 days of tumor growth. Effect of therapy with S247 on the development.

MEDI4736 shows antitumor activity in xenograft mouse models of human cancer. MEDI4736 shows antitumor activity in xenograft mouse models of human cancer.

Effect of the crystal form and solid dispersion preparations of KRN633 on the growth of human tumor xenografts in mice. Effect of the crystal form and.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Comparative effect of anti-TIM3 against experimental tumors.

MGA271 exhibits potent in vivo antitumor activity toward tumor cell carcinoma xenografts. MGA271 exhibits potent in vivo antitumor activity toward tumor.

BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. A, CWR22RV1.

Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors. Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors.

Proliferation of TA3-Ha and TA3-St cells in vitro and in vivo.

Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC xenografts. Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC.

Ceritinib is a potent ALK inhibitor in crizotinib-naïve models.

PLK1 is a crucial downstream effector of PDK1 for MYC activation and cell survival. PLK1 is a crucial downstream effector of PDK1 for MYC activation and.

The cytotoxicity of Bacillus subtilis or surfactin in IPEC-J2 cells.

MET activation confers resistance to cetuximab (Cmab) or panitumumab (Pmab) in colon cancer cell lines in vitro and in vivo. MET activation confers resistance.

Presentation transcript:

Fig. S1 Fig. S1. Experimental design of DSS-induced colitis (A) and AOM/DSS-induced colon carcinogenesis (B).

Fig. S2 Fig. S2. Cytotoxicity of Canolol on mice macrophages (A), human colon cancer Caco-2 cells (B), and human embryonic kidney cells HEK293 (C). 3,000 cells/well were plated in a 96-well plate. After overnight preincubation, Canolol at indicated concentrations was added to the cells. After an additional 48 hours of incubation, cell viability was determined by using the MTT assay. Data are means  SEM (n = 6–8). *, P < 0.05, **, P < See text for details. Mice macrophages A Caco-2 B HEK293 C

Fig. S3 Fig. S3. Effect of canolol against implanted mouse colon cancer (colon 26). Cultured colon 26 cells (2 × 10 6 ) were implanted subcutaneously in the dorsal skin of Balb/c mice. Ten days after tumor inoculation, when tumor reached a diameter of 5-6 mm, canolol (dissolved in corn oil) was orally administration at the dose of 100 mg/kg, corn oil without canolol was used for control mice. Administration was carried out every second day, totally for 3 times. Growth of the tumors was monitored every 2-3 days by measuring tumor volume with a digital caliper, which was estimated by measuring longitudinal cross section (L) and transverse section (W) according to the formula V = (L × W 2 )/2. Data are means  SEM (n = 8). See text for details.