T cell Maturation, Activation & Differentation Hugh B. Fackrell

T cell Maturation, Activation & Differentation Assigned Reading Content Outline Performance Ojectives Key terms Key Concepts Short Answer Questions

Assigned Reading Chapter: 12 pp 285-310 Janis Kuby’s Immunology 3rd Ed

Content Outline T Cell Maturation T helper Cell Activation T Cell Differentiation Peripheral gamma delta T cells

T Cell Maturation Pre T cell receptor T cell development pathways Thymic Selection of T cells positive selection negative selection T helper Cell Activation TCR coupled signaling pathways Co-stimulatory signal Antagonists & Agonists Clonal Expansion Clonal Anergy Superantigens

T Cell Differentiation Effector & memory cells Co-stimulatory differences

Peripherial  T cells Distribution of cells Ligands recognized Functions

Performance Objectives

Key Terms accessory molecules, antigen processing, associatve recogonition model, independent recognition model, cell adhesion molecules, subtractive hybrization

Key Concepts Outline antigen processing and presentation to TCR Describe the molecular pathways for T cell activation Describe positive and negative selection Discuss the role of accessory molecules in T cell antigen recognition

Short Answer Questions

T cell proliferation and differentiation lead to important immunological functions. What are they? Briefly discuss the molecular events, collected called T-Cell activation, that lead to biologic function. What is the importance of diacylglycerol and IP3 in T-cell activation? What transcription factors are involved in T cell activation?

DONE!!!