Imaging Variability in Disease: Epilepsy & Functional Reorganization of Language William Davis Gaillard Children’s National Medical Center G eo Washington.

Slides:

Advertisements

Similar presentations

fMRI Methods Lecture 9 – The brain at rest

Advertisements

1 Challenge the future Multi-scale mining of fMRI data with hierarchical structured sparsity – R. Jenatton et al, SIAM Journal of Imaging Sciences, 2012.

Two aims: 1.Take stock of the dMRI literature on TBI. 2.Make a case for patient specific identification of dMRI abnormalities.

Children Aged 5 to

5S CLÍNICA MÉDICA (MH) 306 A. 5S CLÍNICA MÉDICA (MH) 306 B.

National Alliance for Medical Image Computing Core DBP Dartmouth Data NA-MIC National Alliance for Medical Image Computing

Medical College of Wisconsin Functional Imaging Research Center Stephen M. Rao, Ph.D., Director Professor of Neurology

Reproducibility of diffusion tractography E Heiervang 1,2, TEJ Behrens 1, CEM Mackay 3, MD Robson 3, H Johansen-Berg 1 1 Centre for Functional MRI of the.

Internuclear Ophthalmoplegia in Childhood Shirley H. Wray, M.D., Ph.D. Professor of Neurology, Harvard Medical School Director, Unit for Neurovisual Disorders.

© 2014 Direct One Communications, Inc. All rights reserved. 1 New Insights into the Basic Mechanisms, Diagnosis, and Staging of Epilepsy Nicole Odom, MD.

Neuroimaging of Epilepsy

Functional MRI at the NIH Peter A. Bandettini, Ph.D. Functional MRI Facility, NIMH/NINDS & Unit on Functional Imaging Methods Laboratory.

“I Think My 17 Month Old Baby’s Drunk” Daniel P. Davis, MD UCSD Emergency Medicine.

Bethesda, MD. NCI National Cancer Institute NCCAM National Center for Complementary and Alternative Medicine NCMHD National Center for Minority Health.

“Paying for clinical trials with an SBIR grant” Our experience obtaining millions of dollars through the NIH's Phase II Competing Renewal program Adapted.

PhenX-Sickle Cell Disease Project at the National Heart, Lung, and Blood Institute/NIH Ellen M. Werner, Ph.D. Program Director Blood Epidemiology and Clinical.

Clinical Trials 2008: Genotype/Phenotype Jeffrey L. Neul M.D., Ph.D. Assistant Professor Division of Neurology Department of Pediatrics Assistant Medical.

A New Method for Mapping the Linkage between Abnormal Gray Matter Loss and the Clinical and Cognitive Deficits in Childhood-Onset Schizophrenia 1 Christine.

Basics of Functional Magnetic Resonance Imaging. How MRI Works Put a person inside a big magnetic field Transmit radio waves into the person –These "energize"

Translational Science in Cancer Health Disparities Research Peter Ujhazy, M.D., Ph.D. Program Director Translational Research Program Division of Cancer.

Reproducibility of Functional MRI – Progress Towards Profile Development Use Case: fMRI as a biomarker of functionally eloquent brain cortex for guiding.

Mental Health Insurance Parity: A View from the States David L. Shern, Ph.D. President/CEO Mental Health America Academy Health Policy Conference February.

Thank you: NIMH, NINDS and NICHD Simons Foundation Autism Speaks Cure Autism Now NICHD Brain Bank ATP/Harvard Brain Bank Taran Sierra.

2004 All Hands Meeting Analysis of a Multi-Site fMRI Study Using Parametric Response Surface Models Seyoung Kim Padhraic Smyth Hal Stern (University of.

References: [1]S.M. Smith et al. (2004) Advances in functional and structural MR image analysis and implementation in FSL. Neuroimage 23: [2]S.M.

Neuroplasticity and Rehabilitation Strategies Robert K. Shin M.D. VA MS Center of Excellence Assistant Professor Departments of Neurology and Ophthalmology.

Welcome to Workshop #5: Accelerated Approval (AA) in Rare Diseases: Review of a White Paper Proposal Emil D. Kakkis, M.D., Ph.D. President and Founder.

NIMH MEG Core Facility Magnetoencephalography Imaging Resource, IRP, NIMH / NINDS Comparison of temporal and spatial resolution for various neuroimaging.

INTRODUCTION Chronic pain is associated with cortical functional, neurochemical and morphological changes (Grachev et al., 2002, Apkarian et al., 2004).

Computer Graphics and Image Processing (CIS-601).

Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,

47-year-old with progressive upper limb weakness Teaching NeuroImages Neurology Resident and Fellow Section © 2014 American Academy of Neurology.

STATISTICS FOR HIGH DIMENSIONAL BIOLOGICAL RECORDINGS Dr Cyril Pernet, Centre for Clinical Brain Sciences Brain Research Imaging Centre

NA-MIC National Alliance for Medical Image Computing Mental Illness and Neuroscience Discovery (MIND) Consortium Data Randy L. Gollub,

Cluster Analysis.

The brain at rest. Spontaneous rhythms in a dish Connected neural populations tend to synchronize and oscillate together.

Validation and Refinement of a Prediction Rule to Identify Children at Low Risk for Acute Appendicitis Kharbanda AB, Dudley NC, Bajaj L, et al; Pediatric.

Statistical Analysis An Introduction to MRI Physics and Analysis Michael Jay Schillaci, PhD Monday, April 7 th, 2007.

Familial corneal patterns in pellucid marginal degeneration: uncovering a possible etiology Hajirah N. Saeed, M.D., Amy B. Rosenfeld Ph.D., Xiaowu Gai,

Lydia A. Shrier, MD, MPH David Williams, PhD Division of Adolescent/Young Adult Medicine and the Clinical Research Center, Boston Children’s Hospital Department.

FUNCTIONAL CONNECTIVITY MRI IN PATIENTS WITH BRAIN TUMORS

Geodesic image regression with a sparse parameterization of diffeomorphisms James Fishbaugh 1 Marcel Prastawa 1 Guido Gerig 1 Stanley Durrleman 2 1 Scientific.

Comparison of Risk Factors for Early-Onset versus Late-Onset Alzheimer Disease OBJECTIVE To compare early-onset (before 65) Alzheimer disease (AD) patients.

1 Dept. of Bioimages and Radiological Sciences Catholic University of ROME – ITALY 2 I.T.A.B. – Dept. of Neurosciences “G. d’Annunzio” University – CHIETI.

Peter A. Bandettini, Ph.D. Section on Functional Imaging Methods Laboratory of Brain and Cognition & Functional MRI Facility

Status Epilepticus Presenting After Traumatic Brain Injury in Infants Kurz, J. E.1; Zelleke, T.1; Carpenter, J.1; Dean, N.2; Singh, J.1; Kadom, N.3; Gaillard,

GRAY MATTER ATROPHY IN PEDIATRIC MS PATIENTS

Use of Amyloid PET Scan in Early Diagnosis of Alzheimer’s Disease in a Secondary Care Memory Clinic Niki Schoonenboom, MD PhD1, Mohammed Akarriou, MD2;

#14-A-1124 AAN Department of Neurology and Epidemiology, University of Oklahoma Medical Center; Oklahoma City, OK Cognitive and Behavioral Changes in PSP:

Mentalising music in frontotemporal dementia

20-year-old male with progressive status epilepticus

Results: Behavioral Performance Area and Laterality of activation

Figure 2 The US Centers for Disease Control and

Figure 2 Patterns of brain atrophy in Alzheimer disease

A Unifying Pathophysiologic Approach to The Complications of Diabetes in the Context of the Beta-cell Classification of Diabetes: A Framework for Understanding.

Variable Pretreatment Posttreatment P GFR (mL/min) 115±18 102±14 NS

Figure 1 Hierarchical clustering (HCL) outcome of all tested samples with the expression profile of the case report set as unknown Hierarchical clustering.

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

Mentalising music in frontotemporal dementia

DAT Imaging in a cohort of p.A53T SNCA PD patients versus typical PD

Reading: ‘Washington, DC’

The road map from clinical data generation to natural language processing data enrichment, to machine learning data analysis, to clinical decision making. EMR, electronic.

Hashimoto’s Encephalitis

Figure 4 Pattern of relapse in patients with MOG-Ab Five myelin oligodendrocyte glycoprotein antibody (MOG-Ab)–positive patients experienced a relapse,

Figure 2 Global tau-PET distribution in familial prion disease mirrors the distribution seen in Alzheimer disease Global tau-PET distribution in familial.

The road map from clinical data generation to natural language processing data enrichment, to machine learning data analysis, to clinical decision making. EMR, electronic.

Clinical Concepts Emerging from fMRI Functional Connectomics

Kevin M. Barrett, MD, William D. Freeman, MD Mayo Clinic Proceedings

Axial T2-weighted image (A) demonstrates focal cortical dysplasia (arrow) centered in the left anterior temporal lobe in a right-handed patient. Axial.

Defining diagnostic brain MRI markers in early MSA

Presentation transcript:

Imaging Variability in Disease: Epilepsy & Functional Reorganization of Language William Davis Gaillard Children’s National Medical Center G eo Washington & Georgetown Universities Washington DC Clinical Epilepsy Section, NINDS,NIH Bethesda MD Supported by: Federal Grants R01 NS44280 NINDS, RO1 MH65395 NIMH, P30HD40677 NICHD, U54 MH066417, & Clinical Epilepsy Section NINDS, NIH

Auditory Description Decision Task (ADDT) Group Map: Expected Pattern Individual Maps: Normal & Pathological Variability

Left Partial Epilepsy, MRI, & Atypical Language (n=102) *** *p<0.05 Gaillard, et al. Neurology 2007

ADDT: Inter & Intra-hemispheric Variance Individual vs. group normal SPM voxelwise comparison to id voxels with z>2.0 to generate a patient variance map PCA with hierarchical clustering patient variance maps then grouped into patterns of variance my Kmeans clustering Data displayed as % (penetrance) for voxels with z>2 for each voxel for each group

ADDT: Inter & Intra-hemispheric Variance Normal control SPM map (n=19; mean age 24.8) Patients (n=45; mean age 22.8, onset 13.3), all left hemisphere focus; 73% typical language.

Typical Patient Atypical Patient Individual Patients Compared to Mean Controls

2b 2a 1a 1b 2a&b PCA Identifies Four Groups ADDT n=9 n=16 n=14 n=6