Consequences of Oversizing: Nerve-to-Nerve Tube Diameter Mismatch by Jonathan Isaacs, Satya Mallu, Wo Yan, and Barrett Little J Bone Joint Surg Am Volume.

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Presentation transcript:

Consequences of Oversizing: Nerve-to-Nerve Tube Diameter Mismatch by Jonathan Isaacs, Satya Mallu, Wo Yan, and Barrett Little J Bone Joint Surg Am Volume 96(17): September 3, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Photographs made at time of the initial nerve repairs with the reversed autograft (group A) or with a 14-mm-long conduit of 3 mm (group B), 2 mm (group C), or 1.5 mm (group D) in diameter. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Photographs of examples of conduits from each group at the time of final testing and specimen harvest, three months after implantation. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Histologic specimens from three conduits (toluidine blue, 2×). Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4 Bar graph demonstrating the mean contraction force (and standard deviation) of the reinnervated gastrocnemius muscle normalized with use of data from the control limb. *P < 0.05 compared with group A. #P < 0.05 compared with group B. Exp = experiment... Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Fig. 5 Bar graph displaying mean axon count (and standard deviation) for all groups compared with the control limbs. *P < 0.05 compared with the control limb. Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Histological examples of sections from the experimental nerves (midpart of the graft or conduit) and control nerves from groups A though D twelve weeks after implantation (toluidine blue, 40×). Jonathan Isaacs et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.