A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia by Je-Hwan Lee, Young-Don Joo, Hawk.

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Presentation transcript:

A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia by Je-Hwan Lee, Young-Don Joo, Hawk Kim, Sung Hwa Bae, Min Kyoung Kim, Dae Young Zang, Jung-Lim Lee, Gyeong Won Lee, Jung-Hee Lee, Jae-Hoo Park, Dae- Young Kim, Won-Sik Lee, Hun Mo Ryoo, Myung Soo Hyun, Hyo Jung Kim, Young Joo Min, Yae-Eun Jang, Kyoo-Hyung Lee, and Blood Volume 118(14): October 6, 2011 ©2011 by American Society of Hematology

CONSORT flow diagram. *If patients showed persistent leukemia at interim bone marrow examination (usually 14 days after induction chemotherapy), the second course of induction was given. Je-Hwan Lee et al. Blood 2011;118: ©2011 by American Society of Hematology

Survival differences between the standard-dose (SD-DN) and high-dose daunorubicin (HD-DN) arms. Je-Hwan Lee et al. Blood 2011;118: ©2011 by American Society of Hematology

Subgroup analysis for OS. A univariate Cox proportional hazards model was used to estimate HRs and the significance of the comparison for OS. The horizontal lines represent 95% CIs for the ratios. Je-Hwan Lee et al. Blood 2011;118: ©2011 by American Society of Hematology

Survival differences between the SD-DN and HD-DN arms in terms of cytogenetic risk group. Je-Hwan Lee et al. Blood 2011;118: ©2011 by American Society of Hematology