New Pap Technologies Pap smear screening under scrutiny since late’80s Introduced in ’50s Little change since its introduction Powerful public health measure Morbidity and mortality remain high screening under scrutiny since late’80s Misdiagnosis –false negatives Quality Control

Sources of False Negatives Sampling/preparation errors Cells not collected on collecting device Collected cells not transferred to slide Poor preservation Screening errors Abnormal cells present or missed Interpretive errors

ThinPrep Pap test/ Liquid based cytology Pap Smear Majority of cells not captured Non-representative transfer of cells Clumping and overlapping of cells Obscuring material ThinPrep Majority of sample is collected Randomised representative transfer of cells Even distribution of cells Minimises obscuring material

ThinPrep processing Samples prepared under laboratory conditions Automated capacity Convenient Reproducible