LEHNINGER PRINCIPLES OF BIOCHEMISTRY

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LEHNINGER PRINCIPLES OF BIOCHEMISTRY David L. Nelson and Michael M. Cox LEHNINGER PRINCIPLES OF BIOCHEMISTRY Sixth Edition CHAPTER 3 Amino Acids, Peptides, and Proteins © 2013 W. H. Freeman and Company

Some functions of proteins

Stereoisomerism in amino acids

Conventions to identify carbons in amino acids

Two cysteines can form a cystine, also called a disulfide bond

Amino acids can act as acids and bases

Formation of a peptide bond

The pentapeptide serylglycyltyrosylalanylleucine Ser-Gly-Tyr-Ala-Leu or SGYAL

Amino acid sequence of bovine insulin

Direct Protein Sequencing

Protein sequencing chemistry

Breaking disulfide bonds in proteins