From genomics to Olympics: Exercise as a strategy to help China face the challenges in industrialization Zhen Yan, Ph.D Division of Cardiology Department.

Slides:

Advertisements

Similar presentations

Genesis of Cardiac Arrhythmias Mike Hansen Biology Department Eastern CT State University.

Advertisements

Energy Systems Adaptations to Training

Exercise Science Exercise Physiology.

Project 2 Topic 2 Chronic Adaptations to Training.

Aerobic Conditioning u Muscle Adaptations. Key Points u 1. Muscle adapts to become a more effective energy provider. u An improved capacity for oxygen.

TRAINING ADAPTATIONS Lect. II.

Section A: Applied Anatomy and Physiology 7. Muscle fibre types.

Biology of Lipid Metabolism Laboratory. People Lab head Matthew Watt Research Assistant Maria Matzaris.

Why Lactate is a Friend to Exercise. 1 st : Lactate & H+ temporal relationship b/w  in force & H+ accumulation at same time, metabolic products  : ADP,

Muscle Physiology.

Aging changes of the Musculoskeletal System

BS277 Biology of Muscle. The response of muscle to endurance training. Objectives. After this lecture and associated reading you should be able to; Describe.

Metabolic Review Questions EXS 558 October 5, 2005.

Nieman DC. Exercise Testing and Prescription: A Health-Related Approach. 6/e. Copyright ©2007 McGraw-Hill Higher Education. All rights reserved. Chapter.

Skeletal Muscle State possible sources of fatigue

Maintenance of Bat Skeletal Muscle during Hibernation Kevin Ornee.

New Trends In Strength Training Professor: Exercise Physiology and Biochemistry Director: Exercise Physiology Laboratories Department of Health, Sports.

Weight Training Questions. Is it possible to increase the number of muscle fibers by resistance training?

Designing Resistance Training Programs n Enables clients to engage in physically active leisure-time pursuits, n Perform activities of daily living more.

Collage of medicine Physiology Dep. DR Abdulrahman Alhowikan

KEY KNOWLEDGEKEY SKILLS  Long term (chronic) training adaptations occurring at the cardiovascular, respiratory and muscular systems.  Describe how long.

Behavioral Properties of the Musculotendinous Unit

To understand the cellular processes for synthesis of ATP.

ENERGY SOURCES FOR MUSCLE CONTRACTION. Objectives 1.Energy used 2.Energy produced 3.Oxygen debt 4.Muscle fiber types 5.Muscle fatigue.

Copyright © 2010 Pearson Education, Inc. Muscle Fiber Type Classified according to two characteristics: 1.Speed of contraction: slow fibers or fast fibers.

The Sliding Filament Theory Slide 6.18 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 6.8.

Joellen Little-Kemper November 9, Introduction Imagine that the activation of a single gene could result in increased: *obesity resistance *insulin.

Force of Muscle Contraction

 Chronic training effects are achieved after a period of training, and once produced remains a feature of the body until training ceases. Detraining.

TRAINING ADAPTATIONS (CH11). Training principle of ADAPTATION ALSO REFERRED TO AS THE SAID PRINCIPLE ALSO REFERRED TO AS THE SAID PRINCIPLE S = Specific.

Why Lactate is a Friend to Exercise. 1 st : Lactate & H+ temporal relationship b/w  in force & H+ accumulation at same time, metabolic products  : ADP,

Quiz Ch.9 Part III 1.What is fatigue? 2.What is most likely the cause of muscle fatigue? 3.What are the two main types of contractions? (one describes.

VIII. Types of Skeletal Muscle Fibers A.Categories 1. Color varies according the content of myoglobin, and oxygen storing, reddish pigment a. Red muscles-

The FATZO mouse as a Translational Model for the Development of Drugs for Obesity, Metabolic Syndrome and Diabetes. PreClinOmics, Inc. 1.

15 & 17 October 2008 Muscle Physiology –Properties of individual twitching myofibers –Fiber types –Motor units and whole muscle composition –Fatigue –Recruitment.

Presentation ---Movement & Support

Slow Twitch and Fast Twitch Muscle Fibres Did you eat white meat or dark meat over the holidays?

Good Fat vs Bad Fat and Cancer Prevention

Comparison of different types of muscles Dr. Shaikh Mujeeb Ahmed Assistant Professor Department Basic Medical Sciences Division of Physiology Faculty of.

Completion of Skeletal Muscle and comparison to Smooth Muscle.

Physiological Adaptions in response to training − In response to training the body makes adaptions or adjustments to the level of stress imposed on it.

26 October 2009 This Week in Physiology: Wednesday Quiz: 1 Question based on Today’s Lecture Lab: Muscle Physiology #1 Lectures: Ch. 9 Muscle Physiology.

Sports Physiology Prof. Dr. Bayram Yılmaz Yeditepe University Faculty of Medicine Department of Physiology.

Skeletal Muscle Physiology Muscle excitation and energy sources. Describe the roles of ATP in muscle function. Explain the sources of ATP for muscle function.

Table 1: Characteristics of the Three Muscle Fiber Types Fiber TypeSlow Twitch (ST) Fast Twitch A (FT- A) Fast Twitch B (FT-B) Contraction timeSlowFastVery.

MUSCLE Vince, Chris, Taylor, Cory. PURPOSE How exercise affects muscle How exercise affects muscle How muscle affects exercise How muscle affects exercise.

Section Athletes who excel in a particular sport stay fit by exercising their muscles. 2. Muscles that are not used or are used only for weak.

MUSCLE STRUCTURE. WHAT IS SKELETAL MUSCLE? Muscles are composed of strands of proteins grouped together in fibres. 70% of tissue is water Creates movement.

 Insulin is a peptide hormone released by beta cells when glucose concentrations exceed normal levels (70–110 mg/dL).  The effects of insulin on its.

A “functional biopsy” of muscle properties in sprinters and distance runners Charlie, Kathleen, Diana, Victoria.

Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Oxidative capacity of skeletal muscle in heart failure.

Speaker: Kacy Richmond Advisor: Dr. Jun Ren (School of Pharmacy)

PPAR δ : a dragger in the heart of the metabolic syndrome J.Clin.Invest.116:590~597(2006) R3 Song Se-bin Grant D. Barish, Vihang A.Narkar, and Ronald M.Evans.

Sports Physiology Exercise Physiology Improvements through training.

Chapter 7 Metabolic syndrome

Muscular System.

Myology: the study of skeletal muscles

Unit 1 & 2 past paper questions

by Holly R. Middlekauff Circ Heart Fail Volume 3(4): July 20, 2010

Figure 2 Muscle structure

26 October 2010 This Week in Physiology: Lab: Frog Muscle Physiology

NP D.P. Bx: 9/8/2017.

Post Muscle Contraction

Skeletal muscle physiology

Comparison of Metabolic Abnormalities between PCOS Phenotypes A Hospital-based study LI Hui1,2 LI Lin2 YANG Dong-zi2＃ 1 Bupa Medical Center,

Myoglobin is expressed in oxidative skeletal myofibers.

1QQ # 23 for 8:30 am Fewer mitochondria than Type IIB myofibers.

Presentation transcript:

From genomics to Olympics: Exercise as a strategy to help China face the challenges in industrialization Zhen Yan, Ph.D Division of Cardiology Department of Medicine Duke University Medical Center The 16 th Great Wall International Conference of Cardiology Nov. 5, 2005, Beijing

CHF results in fast-twitch muscle-specific myopathy and mitochondrial disorder

CHF results in decreased mitochondrial oxidative enzyme expression

MHC IIa Dystrophin CD31 Fiber type-specific capillary density determination in mouse skeletal muscle

CHF results in decreased capillarity around type IId/x+IIb fibers

Summary 1.CHF induces multiple abnormalities in fast- twitch, glycolytic fibers in CSQ mice, which may play a primary role in the development of exercise intolerance. 2.Slow-twitch, oxidative fibers seem to be resistant to the pathological insults associated with CHF, which may imply that skeletal muscle contractile activity may protect the myofibers.

Mouse models of obesity and metabolic syndrome Normal chaw High fat