Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA بسم الله الرحمن الرحيم.

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Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA بسم الله الرحمن الرحيم بسم الله الرحمن الرحيم

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdullaziz University. NEOPLASIANEOPLASIA

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA NEOPLASIA What Why Where When How

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA An abnormal mass the growth of which exceeds and is uncoordinated with that of the normal tissue and persists in the same excessive manner after the cessation of stimuli which evoked the change. Definition :

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA DIFINITIONS  TUMOR VS NEOPLASM  ONCOLOGY= ONCOS + LOGOS  BENIGN = RELATIVELY INNOCENT  MALIGNANT = CANCER ( CRAB )

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors: oma + cell type Papilloma : benign surface neoplasm

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors A Polyp : mass projecting above a mucosal surface

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors An Adenoma: benign epithelial neoplasm producing or arising from glands

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors connective tissue Leiomyoma : A benign neoplasm of smooth muscle

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Leiomyoma DR OSAMA I NASSIF FRCPC NEOPLASIA LEIOMYOMA HPF

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Fibroadenoma : more than one cell type, from one germ layer

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign tumors Mixed tumor of salivary glands (pleomorphic adenoma) Derived from one germ layer

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Nomenclature

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign neoplasms Mature teratoma :more than one neoplastic cell type derived from more than one germ layer. Mature teratoma :more than one neoplastic cell type derived from more than one germ layer.

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant tumors

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign Vs malignant

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms differentiation and anaplasia Adenocarcinoma

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Malignant neoplasms Squamous cell carcinoma: Well-differentiated. Differentiation and anaplasia

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Benign vs Malignant

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA Anaplasia Pleomorphism Hyperchromasia High N/C ratio Polynuclearity High mitotic rate Bizarre shapes/sizes Atypical mitoses

Dr. Osama I Nassif. MD, FRCPC. Associate professor & consultant pathologist. Pathology Dept. King Abdulaziz University. NEOPLASIA HAVE A NICE DAY