February 2010 OBO Foundry Meeting Hilmar Lapp Nescent Comparative Data Analysis Ontology

2 History Beginnings CDAO grew out out the NESCent Evolutionary Informatics Working Group A primary objective was to formalize the concepts and relationships important to comparative analysis Recent Publications/Events Initial Implementation of a Comparative Data Analysis Ontology. Evolutionary Bioinformatics. (July 2-09) NESCent Database Interoperability Hackathon (March 2009) TDWG 09 VoCamp (November 2009) Statistics: CDAO Defines 76 Classes 61 Object Properties 10 Datatype Properties

3 Design Overview CDAO is organized around three key concepts Character-State Data Matrix Tree Includes rooted, unrooted, and networks. Data type Categorical Molecular DNA, RNA, Amino-Acids. Standard which includes any categorical data, it's intended as an alignment point for specific categories that a researcher would define. Continuous

4 CDAO Organization

5 Current/Future Work Triple-store A triple-store containing CDAO versions of TreeBase data has been created. The store supports storing arbitrary related rdf The store allows users to upload files in NEXUS, PHYLIP and MEGA formats (NeXML support is in progress) The store has a SPARQL interface Currently a higher-level query interface is being developed to enhance usability and support queries that can not be handled with SPARQL. MIAPA (Minimum Information About a Phylogenetic Analysis) Extend the set of extra annotations to facilitate use with a workflow/provenance framework. Integrate/Align CDAO with other related standards efforts.

6 Acknowledgments Research Collaborators: Arlin Stoltzfus [NIST] F. Prosdocimi and J. Thompson [University of Strasbourg] B. Chisham, B. Wright, T. Le, S. Tran, E. Pontelli [NMSU] Research Support/Sponsors: NSF NMSU CREST Center NESCent NMSU