Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development David O’Sullivan, Gerritje J.W. van der.

Slides:



Advertisements
Similar presentations
How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni
Advertisements

Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice Wing Tak Wong, Xiao Yu Tian, Aimin Xu, Jun Yu, Chi Wai.
Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development Xavier Morin, Yohanns Bellaïche Developmental Cell Volume.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron
Primary Tumor Genotype Is an Important Determinant in Identification of Lung Cancer Propagating Cells Stephen J. Curtis, Kerstin W. Sinkevicius, Danan.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,
Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.
Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair Julian Stingele, Michael S. Schwarz, Nicolas Bloemeke, Peter G. Wolf, Stefan Jentsch.
Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages
Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges
Memory T Cells Officially Join the Stem Cell Club
Amélie Collins, Dan R. Littman  Immunity 
Trained Immunity: An Ancient Way of Remembering
HIV-1 Latency by Transition
An Activation Marker Finds a Function
Alternative Splicing of CD45: The Tip of the Iceberg
TCF-1 Flips the Switch on Eomes
Upgrading from iMac to iMicro
Some DCs Are “B”etter Immunity
Chronic Infections Capture Little Attention of the Masses
miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof
T Helper 17 Cells Get the NOD
Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease
Assessment of Feeding Behavior in Laboratory Mice
CD4 Helpers Put Tissue-Resident Memory Cells in Their Place
Lauren E. Higdon, Michael P. Cancro  Immunity 
Thymic Selection: To Thine Own Self Be True
Anette H.H. van Boxel-Dezaire, M.R. Sandhya Rani, George R. Stark 
Fueling Memories Immunity Volume 36, Issue 1, Pages 3-5 (January 2012)
Chronic Infections Capture Little Attention of the Masses
The Dynamic Cytokine Niche
BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens
Volume 41, Issue 1, Pages (July 2014)
Volume 49, Issue 2, Pages (August 2018)
Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming
A Prescription for Human Immunology
Volume 30, Issue 2, Pages (February 2009)
Volume 38, Issue 1, Pages (January 2013)
One Bug or Another: Promiscuous T Cells Form Lifelong Memory
MicroRNA-155 Function in B Cells
Volume 48, Issue 4, Pages (April 2018)
t Testing the Immune System
Some DCs Are “B”etter Immunity
Of Mice and Men: Not ExAKTly the Same?
TCF-1 Flips the Switch on Eomes
Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease
David Hubel and Torsten Wiesel
IL-9 by INFERence Immunity
Presentation transcript:

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development David O’Sullivan, Gerritje J.W. van der Windt, Stanley Ching-Cheng Huang, Jonathan D. Curtis, Chih-Hao Chang, Michael D. Buck, Jing Qiu, Amber M. Smith, Wing Y. Lam, Lisa M. DiPlato, Fong-Fu Hsu, Morris J. Birnbaum, Edward J. Pearce, Erika L. Pearce Immunity Volume 41, Issue 1, Pages (July 2014) DOI: /j.immuni Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 1 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 2 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 3 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 4 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 5 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 6 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 7 Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions

Immunity , 75-88DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions Terms and Conditions