Lecture 24 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964.

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Lecture 24 Web: pollev.com/ucibio Text: To: Type in:

Regulation

Carbons for amino acids

Amino acids = More than proteins! Creatine Glutathione Heme Nitric oxide Hormones Neurotransmitters

Nucleotide synthesis from many molecules

Synthesis of purines…

…starts on a ribose molecule

A & G from I

Regulation of purine synthesis

Pyrimidine biosynthesis

Regulation

In the presence of CTP, enzyme changes: A. No change in kinetic parameters B. V max increases C. K m increases D. V max decreases, K m increases E. V max decreases, K m increases, k cat increases

Nucleotide metabolism… Still have a MAJOR question… A. Source of C and N for Pu and Py rings B. Regulation of synthesis C. NTP  dNTP D. NMP  NTP E. Difference between plants & animals

Oxy  deOxy

Regulation by reduction!

Regulation of ribonucleotide reductase

The deal with THF

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