U99-2621 #821929720. IgG- strong coarsely granular capillary loop staining,mild to moderate granular peritubular staining IgA- moderate mesangial staining.

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Presentation transcript:

U #

IgG- strong coarsely granular capillary loop staining,mild to moderate granular peritubular staining IgA- moderate mesangial staining with substantial extension to peripheral capillary loops IgM- moderate mesangial staining C3- moderate coarsely granular capillary loop staining,and mesangial staining,mild granular peritubular staining C1q- moderate coarsely granular capillary loop staining,and mesangial staining,mild granular peritubular staining Kappa-moderate mesangial staining with extension to peripheral capillary loops Lambda- moderate coarsely granular capillary loop staining,and mesangial staining Fibrin- mild mesangial staining Albumin- strong hyaline droplet changes in tubular cytoplasm IF

Diagnosis: Renal Biopsy: Diffuse proliferative SLE in a relative inactive phase.

U Native L. Kidney Longstanding discoid SLE renal biopsy >5 years ago with Lupus Nephritis. Stable with N renal function after Cyclophosphamide. Recently increased HTN, increased proteinuria, increased creatinine. Antiphospholipid Syn.

IF IgG- moderate coarsely granular capillary loop staining, IgA- mild to moderate coarsely granular capillary loop staining IgM- mild coarsely granular capillary loop staining C3- mild coarsely granular capillary loop staining C1q- mild to moderate coarsely granular capillary loop staining, Kappa-moderate coarsely granular capillary loop staining Lambda- moderate coarsely granular capillary loop staining Fibrin- moderate interstitial staining Albumin- negative

IgG

IgA

IgM

C3

Clq

Kappa

Lambda

Fibrin

Diagnosis: Renal Biopsy: Membranous Lupus nephritis with probable superimposed chronic infection with scarring and “ thyroid-like” areas in renal parenchyma. Age and hypertension related vascular disease.. EM is pending.