Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle

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Presentation transcript:

Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle

Pyruvate oxidation and the citric acid cycle take place Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Pyruvate oxidation and the citric acid cycle take place in the mitochondrial matrix.

Pyruvate is oxidized to acetate, with the formation of NADH + H+ Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Pyruvate is oxidized to acetate, with the formation of NADH + H+ and the release of CO2. Acetate is activated by combination with coenzyme A, yielding acetyl CoA.

Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Malate is oxidized to oxaloacetate with the formation of NADH + H+. Oxaloacetate can now react with acetyl CoA to reenter the cycle. The two-carbon acetyl group and four-carbon oxaloacetate combine, forming six-carbon citrate. Citrate is rearranged to form its isomer, isocitrate. Fumarate and water react, forming malate. Isocitrate is oxidized to -ketoglutarate, yielding NADH + H+ and CO2 Succinate is oxidized to fumarate, with the formation of FADH2. Succinyl CoA releases coenzyme A, becoming succinate, the energy thus released converts GDP to GTP, which in turn converts ADP to ATP. -Ketoglutarate is oxidized to succinyl CoA with the formation of NADH + H+ and CO2; this step is almost identical to pyruvate oxidation.