Kronlab Glass Columns high quality glass columns for lab scale to process scale solvent resistant and/or biocompatible design designed for low, medium and high pressure column chromatography

Product Lines Eco ECOPLUS Classic BioCart Pilot lab scale low / medium pressure ECOPLUS extended pressure rating up to 80 bar lab scale to prep Classic medium pressure conical tube BioCart lab scale to prep glass cartridges medium to high pressure Pilot pilot scale to production scale custom designed solvent resistant or for aqueous buffers

Pilot Columns for Pilot to Production Scale

Pilot Columns for Pilot to Production Scale designed for use in pilot and production scale designed for use with organic solvents (version SR) or aqueous buffers (version AB) outstanding flow distribution for a linear flow distribution profile high precision manufacturing of plungers and distribution plates with CNC milling machines, no injection moulding involved

Pilot Columns for Pilot to Production Scale full documentation for validation full service and support for custom designed columns materials are in compliance with FDA regulations CFR 21, certified if needed precise and reliable height adjustment of the piston with hand wheels mounted either on castors or fixed stand or directly into customer´s plant

Pilot Columns - Wetted Materials column tube: calibrated borosilicate glass or stainless steel (steel quality to customer‘s specification); optional acrylic piston: PE, PTFE, PVDF or stainless steel seals: EPDM or Kalrez® frits: PE, stainless steel, others on request

Pilot Columns - Sizes columns from 60 mm to 600 mm ID length on demand

Pilot Column - Design of Flow Distributor flow distribution profile proofed by Bayer AG and Kronlab GmbH

Pilot Column - flexible inner diameters PI 100 Cooling Jacket PI 100 Flow distribution profile proofed by Bayer AG and Kronlab GmbH

Pilot Column - flexible column material stainless steel glass or acrylic

Pilot Column - flexible pressure ranges 50 bar 8,7 bar 10 bar 1 bar

Pilot Column - integration of user demands e.g. rotable frames, integrated level indicator, brackets, selected materials, connectors ……….

Pilot Columns - Custom Design special solutions for individual needs regarding: materials design size system integration

Pilot Columns - Custom Design individual feasibility studies and technical drawings certification competent guidance throughout the whole project

Pilot AB - rotatable column id: 200 mm max. bed height: 1600 mm pressure rating: 7 bar specially designed rotatable frame construction

Pilot SR – solvent resistant technical specifications: column id: 200 and 300 mm max. bed height: 400 mm pressure rating: 1.5 bar explosion-proof environment with antistatic protection and wheels

Pilot SR – stainless steel technical specifications: column id: 100 mm max. bed height: 1000 mm min bed height: 500 mm pressure rating: 40 bar sealing: Kalrez®

Pilot SR – stainless steel technical specifications: column id: 150 mm max. bed height: 900 mm min bed height: 700 mm pressure rating: 50 bar sealing: Kalrez®

Pilot AB - Reactor id: 300 mm bed height: 0- 500 mm pressure rating: 1 bar frit: 30 µm (SS 1.4404) special features: slurry inlet integrated magnetic stirrer on cambered bottom frit piston with scraper special designed column stand

Pilot AB -rotatable id: 240 mm bed height: 0 - 270 mm volume: 0-12 l pressure rating: 3 bar cooling jacket: 15 - 65°C SS - container: 15 l for slurry waste frits: 10 µm PE 5 mm thickness specially designed frit fastening screws to ensure perfect flow distribution

Pilot Columns - stainless steel id: 600 mm max. bed height: 1000 mm (1500 mm) bed volume: 282,6 l (423,9 l) pressure rating: 10 bar frits: 10 µm

Pilot Column - stainless steel Example Pilot Column - stainless steel id: 600 mm max. bed height: 1000 mm (1500 mm) bed volume: 282,6 l (423,9 l) pressure rating: 10 bar frits: 10 µm designed for repeated packing and unpacking without opening the column

Example Solvent Inlet Slurry-Inlet through separate slurry pump Slurry-Outlet through central outlet valve Solvent Outlets

Pilot Columns - References Abbott Aventis Baxter Hyland Immuno AG Bayer AG Biotest Clariant Genetics Institute Genzyme Honeywell Novartis AG Schering AG Roche Diagnostics etc …