Effect of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization on Tendon-Bone Healing After ACL Reconstruction in a Rat Model by Robert H.

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Presentation transcript:

Effect of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization on Tendon-Bone Healing After ACL Reconstruction in a Rat Model by Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, and Scott A. Rodeo J Bone Joint Surg Am Volume 93(4): February 16, 2011 ©2011 by The Journal of Bone and Joint Surgery, Inc.

Example of mounted external fixator on specimen with Keith needle in place. Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Example of animal connected to loading device. Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Example of negative control histology (mouse anti-rat ED1– microphage stain; original magnification, ×20). Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

ED1 staining (mouse anti-rat ED1-macrophage stain) showing inflammatory macrophages in the tissue of a rat from the immobilized group killed at two weeks (original magnification, ×20). Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Factor VIII staining (rabbit anti-human factor VIII, DAKO) showing endothelial cells in the tissue of a rat from the immobilized group killed at four weeks (original magnification, ×20). Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Procollagen staining (Santa Cruz Biotechnology) revealing collagen synthesis in the tissue of a rat from the immobilized group killed at four weeks (original magnification, ×20). Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Graph showing the mean daily loading curve (and standard deviation) of the rats that underwent daily loading for two weeks or four weeks. Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Graph showing the mean stiffness data (and standard deviation) from isolated bone-tendon- bone specimens. Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Graph showing the mean load-to-failure data (and standard deviation) from isolated bone- tendon-bone specimens. Robert H. Brophy et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.