CONTACT NUMBERS TEL:(202)745-8330 FAX: (202)462-2006 DR. RAJ LAKSHMAN PROFESSOR OF BIOCHEMISTRY, MOLECULAR BIOLOGY & MEDICINE.

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CONTACT NUMBERS TEL:(202) FAX: (202) DR. RAJ LAKSHMAN PROFESSOR OF BIOCHEMISTRY, MOLECULAR BIOLOGY & MEDICINE

Mechanisms of Actions of Alcohol & Omega3-Fatty Acids.  To delineate the mechanisms of actions of alcohol and omega3-fatty acids in altering the post-translational modifications of glycoproteins and their functions. Light & Heavy Alcohol, Paraoxonase & Oxidized LDL Status.  The major goal of this project is to evaluate the benefits and deleterious effects of moderate and heavy drinking on cardiovascular risk factors DR. LAKSHMAN’S FUNDING NIH GRANTS

ST6 Gal 1 mRNA Protein Complex UNSTABLE ST6 Gal 1 mRNA Normal CH Efflux LCAT Apo-E Cholesterol Loaded Macrophage Asialo- conjugates PL Free CH HDL3 HDL2 LIVER CELL BLOOD COMPARTMENT ST6 Gal 1 3’UTR Binding Protein (~41kD) Normal ST6Gal1 Sialo- conjugates X CHE VLDL Associates weakly with Associates strongly with Cholesterol uptake ω3-Fatty Acids Actions of Alcohol & Omega3-Fatty Acids

HDL-PON LDL OX-LDL Plaque Macrophage Inactive products Up-regulated by light ethanol Down-regulated by heavy ethanol Foam Cell Bimodal Action of Alcohol on PON & CAD Status