Excitation-contraction coupling and drugs W. Rose.

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Excitation-contraction coupling and drugs W. Rose

Normal skeletal excitation-contraction coupling L-type Ca chnl(=DHPR) physically coupled to SR Ca release chnl(=RyR). Ca influx not required for SR Ca release.

Normal excitation-contraction coupling in cardiac muscle Cardiac: L-type Ca chnl not physically coupled to RyR. Ca influx thru L-type Ca chnl triggers opening of SR Ca chnl and hence SR Ca release.

Man-made chemicals and drugs that affect excitation-contraction coupling Caffiene: RyR DHP: blocks L-type Ca channel Triclosan (hand sanitizer): impairs contractility in skeletal and cardiac muscle in mice; blocks L-type Ca channel. Triclosan: Cherednichenko et al., PNAS 2012.