Full-Length spp24, but Not Its 18.5-kDa Proteolytic Fragment, Inhibits Bone-Healing in a Rodent Model of Spine Fusion by Chananit Sintuu, Robert J. Simon,

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Presentation transcript:

Full-Length spp24, but Not Its 18.5-kDa Proteolytic Fragment, Inhibits Bone-Healing in a Rodent Model of Spine Fusion by Chananit Sintuu, Robert J. Simon, Masashi Miyazaki, Yuichiro Morishita, Henry J. Hymanson, Cyrus Taghavi, Elsa J. Brochmann, Samuel S. Murray, and Jeffrey C. Wang J Bone Joint Surg Am Volume 93(11): June 1, 2011 ©2011 by The Journal of Bone and Joint Surgery, Inc.

Bar graph showing the radiographic evidence of bone formation at the L4-L5 fusion site over time and according to the various rhBMP-2 doses given. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Bar graph showing the radiographic evidence of bone formation in samples treated with both rhBMP-2 and the recombinant isoform of spp24. a: Bone area for animals implanted with 1 μg of rhBMP-2 plus varying doses of truncated spp18 (TR-spp18) (left) or full-... Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

a: Dose response of rhBMP-2-mediated bone formation, as determined by manual assessment of bone formation. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Representative microquantitative computed tomography images of spines treated with rhBMP-2 and harvested at varying time points. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Representative anterior and lateral microquantitative computed tomography images of specimens treated with truncated spp18 (TR-spp18) with or without rhBMP-2. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Representative anterior and lateral microquantitative computed tomography images of specimens treated with full-length spp24 (FL-spp24) with or without rhBMP-2. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Hematoxylin-and-eosin-stained sagittal sections of control spines. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Hematoxylin-and-eosin-stained sagittal sections of spines implanted with truncated spp18 (TR- spp18) and rhBMP-2. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.

Hematoxylin-and-eosin-stained sagittal sections of spines implanted with full-length spp24 (FL- spp24) and rhBMP-2. Chananit Sintuu et al. J Bone Joint Surg Am 2011;93: ©2011 by The Journal of Bone and Joint Surgery, Inc.