CMACS 2013: USING THE TEN-TUSSCHER MODEL GROUP 1- ANOOPA SINGH, KATARZYNA GOLEC, TOVA NEUBERGER.

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Presentation transcript:

CMACS 2013: USING THE TEN-TUSSCHER MODEL GROUP 1- ANOOPA SINGH, KATARZYNA GOLEC, TOVA NEUBERGER

WAIT…WHAT ARE WE DOING? Using a 12 variable model to simulate atrial fibrillations of the heart. Parameters of importance were ion channels & their conductance. Our variables were GNa [the conductance of the sodium channel] and GCaL [the conductance of the calcium leak channel] Our variables allowed us to delve into the relationship between the action potential duration and the stability of a spiral wave…more on that later.

EXCITABLE SYSTEMS! Like the saline oscillator! Variables to vary: thickness, orifice size, saline solution concentration and area of smaller chamber

MORE EXCITABLE SYSTEMS Belousov- Zhabotinsky Reaction

A WORD ON ACTION POTENTIALS: FIRST, NEURAL There are neural Aps as well as cardiac APs- an understanding of both is crucial

AND MORE IMPORTANTLY, CARDIAC

THE IMPORTANCE OF SODIUM AND CALCIUM Sodium: in cardiac cells, STARTS the depolarization. Without sodium, there would be no action potential. But with excess sodium, what happens? Calcium: In cardiac cells MAINTAINS the action potential over time- is the major difference between neural and cardiac action potentials. Necessary because without calcium extending depolarization, the heart muscle cannot contract.

RESULTS!

CLICK US! someindividual.com/cmacs/group1_spirals.png someindividual.com/cmacs/group1_paths.png someindividual.com/cmacs/group1-2_paths.png

CONCLUSIONS

TIP TRAJECTORIES GET MORE CHAOTIC WHEN THERE IS MORE SODIUM OR CALCIUM

DURING THE SECOND RUN, MORE THAN ONE TIP TRAJECTORY APPEARED

SPIRAL WAVE VARIATIONS

MANY THANKS TO Nancy Griffeth Flavio Fenton Robert Gilmour Bard Ermentrout Aron Wolinowitz Charles Beard Rachel Spratt Daniel Packer And of course, Peter Valdez

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