Chapter 11 Cell Communication. Local signaling: Paracrine Synaptic Long distance signaling: Hormonal. Chapter 11 Cell Communication.

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Presentation transcript:

Chapter 11 Cell Communication

Local signaling: Paracrine Synaptic Long distance signaling: Hormonal. Chapter 11 Cell Communication

Stage I: Reception Chapter 11 Cell Communication

Stage I: Reception Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage II: Transduction Chapter 11 Cell Communication

Stage III: Response Chapter 11 Cell Communication

Stage III: Response Chapter 11 Cell Communication

Ligand: A molecule that binds specifically to another molecule. Chapter 11 Cell Communication

Three kinds of surface receptors: G-protein linked receptors Receptor tyrosine kinases Ion channel receptors (Kinase = enzyme that transfers phosphate groups.) Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication G-protein GDP GTP enzyme

G-protein linked receptors Chapter 11 Cell Communication G-protein enzyme GTP GDP

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

G-protein linked receptors Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication ATP ATP ATP Tyr Relay proteins

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Receptor Tyrosine Kinase Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

Ion channel receptor Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication ATP Protein kinases Inactive protein Relay molecule

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication Why bother with such a complicated system?

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

A Phophosphorylation Cascade Chapter 11 Cell Communication

Scaffolding proteins and specificity Chapter 11 Cell Communication

Scaffolding proteins and specificity Chapter 11 Cell Communication

Scaffolding proteins and specificity Chapter 11 Cell Communication

Scaffolding proteins and specificity Chapter 11 Cell Communication

Scaffolding proteins and specificity Chapter 11 Cell Communication

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