Total synthesis of Piperazic acid-containing natural products: Piperazimycin A and Chloptosin Liu Bin 2013-3-23.

Slides:

Advertisements

Similar presentations

For(int i = 1; i

Advertisements

Prepared by : Malak Eshtayah

CDC Reaction Involving α -C-H Bonds of Nitrogen in Amines 李南

Iron-catalyzed Cross Coupling reactions: From Rust to a Rising Star

Iron Catalyzed Cross-Coupling Reaction: Recent Advances and Primary Mechanism Wang Chao

Rhodium Catalyzed Direct C-H Functionalization 陈殿峰

Catalytic Cross-coupling Reactions with Unactivated Alkyl Electrophiles and Alkyl Nucleophiles Heng Su 04/11/2008 Department of Chemistry Brandeis University.

Reporter: Yu Ting Huang Advising Prof: Ru Jong Jeng 1.

(-)-Kendomycin Angew. Chem. Int. Ed. 2009,48,()

Enantioselective Total Synthesis of Ecteinascidin 743

Synthesis of Gelsemine Alexander J. L. Clemens Burke Group October 26, 2006.

1 Single electron transfer reaction involving 1,3-dicarbonyl compounds and its synthetic applications Reporter: Jie Yu Oct. 31, 2009.

Recent Progress in sp 3 C-H Activation Catalyzed by Palladium Bo Yao.

何玉萍 Palladium(II)-Catalyzed Alkene Functionalization.

The Career of Chao-Jun Li Guochang B.S. Zhengzhou University 1979 M.S. Chinese Academy of Science 1985 Tak-Hang ChanTak-Hang Chan Ph.D. McGill.

Career-in-review Keiji Maruoka Reporter: Li Chen Supervisor: Prof. David Zhigang Wang

Reactions Catalyzed by Rhenium Carbonyl Complexes 杜宇鎏

Amide bond formation and peptide coupling Mgr. Juraj Dobiaš KOCH PRIF UK Ch. A. G. N., Montalbetti; V., Falque Tetrahedron 2005, 61, 10827–10852.

任磊 Barry M. Trost J. AM. CHEM. SOC. 2006, 128, 不对称烯丙基化.

Synthesis and Biological Activity of Platensimycin

High-Oxidation-State Palladium Catalysis 报告人：刘槟 2010 年 10 月 23 日.

Total Synthesis of Communesins Jian-Zhou Huang

Litterature Meeting Enantioselective Total Synthesis of Avrainvillamide and Stephacidins A and B Aspergillus ochraceus.

1 DNA-Templated Synthesis: Principles of Evolution in Organic Chemistry.

Peptidomimetics and Mimicry of  -Strand / Sheets and  -Sheet Sandwiches Jian Liu Merck & Co., Inc. Rahway, NJ

Synthesis of meso-substituted porphyrins

Mingli Li ( stored as THF solutions, blue-green for SmI 2 and yellow-green for YbI 2 ) Deoxygenation Reactions Reductions of Double Bonds.

Ye Zhu 09/02/10 Burgess’s Group Meeting Chiral Ligands On A Spiro Scaffold for Transition-Metal- Catalyzed Asymmetric Reactions Work by Prof. Zhou Qi-Lin.

Utilization of Ring Closing Metathesis in Alkaloid Synthesis I. Synthetic Studies on the Immunosuppressant FR II. Toward the Total Synthesis of Lundurines.

1 Chiral Phosphoric Acids-Catalyzed Multi-Component Reactions for Synthesis of Structurally Diverse Nitrogenous Compounds Feng Shi Dec. 18th, 2010.

Ru-Catalyzed C-H Activation Wang cheng ming

Supervisor: Yong Huang Reporter: Qian Wang Date: Magical Chiral Spirobiindane Skeletons.

Rhodium-Catalyzed Chemo- and Regioselective Decarboxylative Addition of β- Ketoacids to Allenes: Efficient Construction of Tertiary and Quaternary Carbons.

Regioselective reactions of 3,4-pyridynes enabled

The Work Of Pr Karl A. Scheidt Group Department of Chemistry, Northwestern UniVersity, Evanston.

Redox Neutral Reactions Wang Chao Redox Economy and Redox Neutral Reactions: Angew. Chem. Int. Ed. 2009, 48, 2854 – 2867.

Spectral Interpretation General Process for Structure Elucidation of an Unknown Nat. Prod. Rep., 1999, 16,

Indium in Organic Synthesis Huang-Jianzhou

Reporter: Yang Chao Supervisor: Prof. Yong Huang The Transformation of α ‑ Diazocarbonyl Compounds.

C-H Insertion Story Justin Du Bois associate professor : University of Stanford B.S. : University of California at Berkeley (1992) Ph.D. : California Institute.

Organic Pedagogical Electronic Network Applications of C–H Functionalization in Total Synthesis Sorensen Lab, Princeton University.

Nicolas Gaeng Group seminar – LSPN – 30/04/15. Structures with multiple rings connected through one atom Nomenclature proposed by Adolf Baeyer in 1900.

Selected examples of Domino Reactions in Total Synthesis Dagoneau Dylan Zhu Group Frontiers in Chemical Synthesis May 22 th, 2014.

Enantioselective Total Synthesis of Plectosphaeroic acid B J. Am. Chem. Soc. 2013, 133, 6549−6552 Salman Y. Jabri and Larry E. Overman* Speaker: 古宜加.

Total Synthesis of (—)-Acetylaranotin Hideto Fujiwara, Taichi Kurogi, Shun Okaya, Kentaro Okano, and Hidetoshi Tokuyama* Angew. Chem. Int. Ed. 2012, 51,

Enzymatic and Chemoenzymatic Carbohydrate Synthesis Group Meeting Presentation April 20, 2016 Kelly Craft.

Methods for α-Sialylation Caroline Braun Townsend Group Meeting May 11, 2016.

Catalytic Enantioselective Fluorination

Acyl chlorides.

Recent Development in Isocyanide-Based

Presented by Guillaume Pelletier. March 11th 2008.

Transition Metal Catalyzed Amide Bond Formation

Total Synthesis of (±)-Cylindricine C

Mike Mulholland Literature Meeting October 23rd 2012

Wavelength Tunability

Enantioselective Total Synthesis of (+)-Gelsemine

Michael J. Krische Presented by Louis-Philippe Beaulieu

Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes

Acyl chlorides.

Total Synthesis of (-)-Conophylline

Ke Kong, John A. Enquist, Jr. , Monica E. McCallum, Genessa M

Synthesis of Biyouyanagin A

C-H Insertion of Rhodium-Carbene Using Diazo Compounds

Copper Catalyzed C-N Bond Formation Using O-Acyl Hydroxylamine

Thin Film Growth of Amorphous Metal Phosphorus Alloys

Carbon Monoxide “Insertion”

Kiyoun Lee and Dale L. Boger*

Principles of Organic Synthesis in Pure Water

Problem Set – Litterature

Presentation transcript:

Total synthesis of Piperazic acid-containing natural products: Piperazimycin A and Chloptosin Liu Bin

Alexander J. Oelke, Steven V. Ley, etc. Angew. Chem. Int. Ed. 2010, 49, 6139 Shun-Ming Yu, Zhu-Jun Yao. etc. Org. Lett. 2010, 12, Theodore M. Kamenecka, Samuel J. Danishefsky. Angew. Chem. Int. Ed. 1998, 37, 2993 Wenhua Li, Dawei Ma. etc. Angew. Chem. Int. Ed. 2009, 48, 8891

Key challenges: 1) formation of the piperazic acid– piperazic acid dipeptide moiety 2) formation of the macrocycle by macrolactonisation

Generation of acyl azides for peptide coupling 2. 1.

Feature: enantioselective preparation of the piperazic acid

Generation of acyl chloride for peptide coupling

谢