Additional file 1: Summary of E-painting results for human chromosomes The human chromosome coordinates of the breakpoint intervals are given to the right of the human ideogram in Mb. The chromosome numbers of the orthologous segments in the analyzed species are indicated to the right of the conserved segments. Chromosomal breakpoints have been evenly spaced in order to facilitate visualization of the conserved syntenic segments. The resulting ideograms of the chromosomes and conserved segments are therefore not drawn to scale. The centromeric region is indicated by a black horizontal bar. The stippled red lines indicate breaks present in all analyzed vertebrate genomes which may therefore be attributed to rearrangements in the primate lineage.

human rat mouse dog cow chicken – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – un HSA 1 opossum – –

25.47 – – – – – – – – – – – – – – – – – – Un – – – – – – – – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 2 opossum

10.30 – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 3 opossum

– Z – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 4 opossum

01.69 – – – – – – – – – – – Z – – – – – – Z – – – – – Z – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 5 opossum

25.81 – Histone Cluster – – – – – – – – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 6 opossum

06.64 – – – – – – – – – – – – – – – – – – – un – – – – – – – – – – – un – – – – – – – human rat mouse dog cow chicken HSA 7 opossum

00.48 – – – un – – – – – – – – – – – – Z – un – Z – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 8 opossum

05.82 – – – – – – – – – – Z – – – Z – – Z – – Z – – – human rat mouse dog cow chicken HSA 9 opossum

03.82 – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 10 opossum

01.01 – – – – – – – – – – – – – – un – – un – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 11 opossum

07.55 – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 12 opossum

25.52 – – – – – 51: – – – – – human rat mouse dog cow chicken HSA 13 opossum

00.00 – – – – – – – – – – – – human rat mouse dog cow chicken HSA 14 opossum

00.00 – – – – – – – – – – – – – – ? – – – human rat mouse dog cow chicken HSA 15 opossum

00.16 – – – – – un – – – – – un – – human rat mouse dog cow chicken HSA 16 opossum

03.77 – – – un – – – – – – – – – – – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 17 opossum

00.57 – – – – – – Z – – – Z – – human rat mouse dog cow chicken HSA 18 opossum

01.16 – – Z – – un – – – – – – – – un – – – – – un human rat mouse dog cow chicken HSA 19 opossum

02.36 – – un – – – – – – – – – – – – – – – – – – human rat mouse dog cow chicken HSA 20 opossum

42.30 – – – – – – – human rat mouse dog cow chicken HSA 21 opossum

00.00 – – – – – – – – – – human rat mouse dog cow chicken HSA 22 opossum

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