1 2. Nucleic acids and proteins in one and more dimensions

Protein sequence data banks 2 2. Nucleic acids and proteins in one and more dimensions

3 Protein sequence data banks

2. Nucleic acids and proteins in one and more dimensions 4 Protein sequence data banks

2. Nucleic acids and proteins in one and more dimensions 5 Protein sequence data banks

6 2. Nucleic acids and proteins in one and more dimensions Protein sequence data banks

7 2. Nucleic acids and proteins in one and more dimensions

8 what to do with sequences? 2. Nucleic acids and proteins in one and more dimensions

9 GXXXXGK(T/S) ATP or GTP binding site protein sequence annotation what to do with sequences? 2. Nucleic acids and proteins in one and more dimensions

10 2. Nucleic acids and proteins in one and more dimensions functions from nucleotide sequence protein 3D structure

Nucleic acids and proteins in one and more dimensions

Proteins: different functions and architectures Nucleic acids and proteins in one and more dimensions

13 Proteins: not all structures are equally possible 2. Nucleic acids and proteins in one and more dimensions

Gopalasamudram Narayana Iyer Ramachandran φ ψ Nucleic acids and proteins in one and more dimensions

Gopalasamudram Narayana Iyer Ramachandran φ ψ φ ψ Nucleic acids and proteins in one and more dimensions

16 2. Nucleic acids and proteins in one and more dimensions Gopalasamudram Narayana Iyer Ramachandran

17 2. Nucleic acids and proteins in one and more dimensions

side chain conformation Torsion Axes and Dihedral Angles of the side chain of Lysine The sample amino acid Lysine has four torsion axes within its side chain. The torsion axes are symbolized as arrows, the dihedral angles are labeled chi1 to chi Nucleic acids and proteins in one and more dimensions

α helix in α-helix hydrogen bonds between carbonyl i and amide i Nucleic acids and proteins in one and more dimensions

Folding mechanism of alpha helices 20 α helix 2. Nucleic acids and proteins in one and more dimensions

φ ψ α helix and Nucleic acids and proteins in one and more dimensions

22 β strands and β sheets 2. Nucleic acids and proteins in one and more dimensions

23 β strands and β sheets 2. Nucleic acids and proteins in one and more dimensions

24 β strands and β sheets 2. Nucleic acids and proteins in one and more dimensions

25 β strands and β sheets 2. Nucleic acids and proteins in one and more dimensions

26 filamenti β formano foglietti β 2. Nucleic acids and proteins in one and more dimensions

turns and loops Nucleic acids and proteins in one and more dimensions

(e) 28 structural motifs or supersecondary structures 2. Nucleic acids and proteins in one and more dimensions

29 protein domains 2. Nucleic acids and proteins in one and more dimensions

30 protein domains Glyceraldehyde 3-Phosphate NAD Glyceraldehyde 3-Phosphate dehydrogenase 2. Nucleic acids and proteins in one and more dimensions

31 protein domain assembly 2. Nucleic acids and proteins in one and more dimensions

Quaternary Structure heteromultimers homomultimers Nucleic acids and proteins in one and more dimensions

X ray diffraction Cryo-electron microscopy Nuclear Magnetic Resonance (NMR) Nucleic acids and proteins in one and more dimensions Guided tour of Protein Data Bank three techniques to make it growing

2. Nucleic acids and proteins in one and more dimensions 34 Guided tour of Protein Data Bank

2. Nucleic acids and proteins in one and more dimensions 35 Guided tour of Protein Data Bank B factor occupancy

2. Nucleic acids and proteins in one and more dimensions 36

2. Nucleic acids and proteins in one and more dimensions

2. Nucleic acids and proteins in one and more dimensions 38 how to install PyMOL